◀ Back to RENBP

MMP13 — RENBP

Text-mined interactions from Literome

Rasheed et al., Arthritis Res Ther 2009 : In the present study, we examined the effect of epigallocatechin-3-gallate ( EGCG ) on AGE-modified-BSA (AGE-BSA) induced activation and production of TNFalpha and MMP-13 in human OA chondrocytes ... EGCG significantly decreased AGE stimulated gene expression and production of TNFalpha and MMP-13 in human chondrocytes ... The inhibitory effect of EGCG on the AGE-BSA induced expression of TNFalpha and MMP-13 was mediated at least in part via suppression of p38-MAPK and JNK activation
Huang et al., Rheumatology (Oxford) 2011 (Osteoarthritis) : AGE enhanced expression and enzyme activity of MMP and ADAMTS genes and resulted in reduction of collagen II ... Both janus kinase 2 (JAK2) and JAK3 inhibitors suppressed AGE induced MMP-13 , ADAMTS-4 and ADAMTS-5 expression and enzyme activity ... In addition, interference of STAT3 expression inhibited AGE induced MMP-13 and ADAMTS enzyme activities and mRNA levels ... Blocking JAK/STAT3 signalling pathway inhibited AGE induced activation of MMP-13 and ADAMTS and prevented AGE mediated decrease of collagen II and proteoglycan ( aggrecan )
Yang et al., Pharmacology 2013 : In the present study, we examined the effect of curcumin, a pharmacologically safe phytochemical agent, on AGE induced tumor necrosis factor-a (TNF-a) and matrix metalloproteinase-13 (MMP-13) in rabbit chondrocytes