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PCNA — SP1

Text-mined interactions from Literome

Kivinen et al., Oncogene 1999 (MAP Kinase Signaling System) : Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1 binding sites
Kim et al., Biochem Biophys Res Commun 2006 : Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E2F binding sites in the cyclin E promoter, as evidenced by the fact that specific inhibition of Sp1 leads to a decrease in apicidin activation of cyclin E promoter activity and protein expression, but mutation of E2F binding sites of cyclin E promoter region fails to inhibit the ability of apicidin to activate cyclin E transcription
Ai et al., Biochem Biophys Res Commun 2007 (Carcinoma...) : Arsenic trioxide mediated growth inhibition in gallbladder carcinoma cells via down-regulation of Cyclin D1 transcription mediated by Sp1 transcription factor ... Taken together, these results suggested that arsenic trioxide inhibited gallbladder carcinoma cell proliferation via down-regulation of Cyclin D1 transcription in a Sp1 dependent manner, which provided a new mechanism of arsenic trioxide involved cell proliferation and may have important therapeutic implications in gallbladder carcinoma patients