Gene interactions and pathways from curated databases and text-mining

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PCNA — PLK1

Text-mined interactions from Literome

Lacey et al., Proc Natl Acad Sci U S A 1999 : Cyclin dependent kinase control of centrosome duplication
Takai et al., Cancer Lett 2001 (Adenocarcinoma...) : However, the expression of proliferating cell nuclear antigen , Ki-67, and cyclin B1 was independent of PLK expression
Takai et al., Cancer Lett 2001 (Carcinoma...) : However, the expression of proliferating cell nuclear antigen and Ki-67 was independent of PLK expression
Okano-Uchida et al., EMBO J 2003 : When Plk1 was required for cyclin B-Cdc2 activation, the action of Plk1 was mediated primarily through suppression of Myt1 rather than through activation of Cdc25
Mitra et al., Cell cycle (Georgetown, Tex.) 2006 : In mammalian somatic cells, the Anaphase Promoting Complex (APC) is inactivated during S phase by active cyclin A-Cyclin dependent kinase (Cdk) 2 complexes promoting accumulation of mitotic regulators, such as cyclin B and Polo like kinase 1 (Plk1)
Merkerova et al., Leuk Res 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : PCNA inhibition led to down-regulation of CDK1, CDK4, PLK1 , ERK3, JNK1, STAT5, and several inhibitors of apoptosis ( DAXX, Mdm2, survivin )
Bonnet et al., Biochem Biophys Res Commun 2008 : Activation of Cdc25C at the G2/M transition, involves its dissociation from 14-3-3, together with its hyperphosphorylation on several sites within its regulatory N-terminal domain, mediated by cyclin dependent kinases and Plk1
Raychaudhuri et al., Cancer Res 2011 (Neoplasm Metastasis...) : The transcriptional activity of FoxM1 depends upon activation by cyclin and cyclin dependent kinases as well as Plk1
Down et al., Biochim Biophys Acta 2012 : FoxM1 transcriptional activity requires sequential phosphorylation by Cyclin dependent kinases and Plk1 , which are B-Myb target genes, and we found that phosphorylation at Plk1-specific sites was somewhat reduced upon B-myb knockout
Zhang et al., BMC systems biology 2012 : These results suggest that the reaction process in which the activated cyclin-CDK1 activates the Plk1 has a very important influence on the synchronization ability of the coupled system, and the square-wave periodic signal of cyclin synthesis is more conducive to the synchronization and robustness of the coupled cell-cycle oscillators
Qian et al., Science 1998 : The Xenopus polo-like kinase 1 ( Plx1 ) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation
Arnaud et al., Chromosoma 1998 : In vertebrates, Plks participate in centrosome maturation and spindle assembly, as well as the activation of the Cdk1/cyclin B complex