◀ Back to PCNA
PCNA — PLK1
Text-mined interactions from Literome
Lacey et al., Proc Natl Acad Sci U S A 1999
:
Cyclin dependent kinase control of
centrosome duplication
Takai et al., Cancer Lett 2001
(Adenocarcinoma...) :
However, the expression of
proliferating cell nuclear antigen , Ki-67, and cyclin B1 was
independent of
PLK expression
Takai et al., Cancer Lett 2001
(Carcinoma...) :
However, the expression of
proliferating cell nuclear antigen and Ki-67 was
independent of
PLK expression
Okano-Uchida et al., EMBO J 2003
:
When
Plk1 was
required for
cyclin B-Cdc2 activation, the action of Plk1 was mediated primarily through suppression of Myt1 rather than through activation of Cdc25
Mitra et al., Cell cycle (Georgetown, Tex.) 2006
:
In mammalian somatic cells, the Anaphase Promoting Complex (APC) is inactivated during S phase by active
cyclin A-Cyclin dependent kinase (Cdk) 2 complexes
promoting accumulation of mitotic regulators, such as cyclin B and
Polo like kinase 1 (Plk1)
Merkerova et al., Leuk Res 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
PCNA inhibition
led to down-regulation of CDK1, CDK4,
PLK1 , ERK3, JNK1, STAT5, and several inhibitors of apoptosis ( DAXX, Mdm2, survivin )
Bonnet et al., Biochem Biophys Res Commun 2008
:
Activation of Cdc25C at the G2/M transition, involves its dissociation from 14-3-3, together with its hyperphosphorylation on several sites within its regulatory N-terminal domain, mediated by
cyclin dependent kinases and
Plk1
Raychaudhuri et al., Cancer Res 2011
(Neoplasm Metastasis...) :
The transcriptional activity of FoxM1 depends upon activation by cyclin and
cyclin dependent kinases as well as
Plk1
Down et al., Biochim Biophys Acta 2012
:
FoxM1 transcriptional activity requires sequential phosphorylation by
Cyclin dependent kinases and
Plk1 , which are B-Myb target genes, and we found that phosphorylation at Plk1-specific sites was somewhat reduced upon B-myb knockout
Zhang et al., BMC systems biology 2012
:
These results suggest that the reaction process in which the activated
cyclin-CDK1 activates the
Plk1 has a very important influence on the synchronization ability of the coupled system, and the square-wave periodic signal of cyclin synthesis is more conducive to the synchronization and robustness of the coupled cell-cycle oscillators
Qian et al., Science 1998
:
The Xenopus
polo-like kinase 1 ( Plx1 ) is
essential during mitosis for the activation of Cdc25C, for spindle assembly, and for
cyclin B degradation
Arnaud et al., Chromosoma 1998
:
In vertebrates, Plks participate in
centrosome maturation and spindle assembly, as well as the
activation of the
Cdk1/cyclin B complex