Gene interactions and pathways from curated databases and text-mining

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CDC40 — PCNA

Text-mined interactions from Literome

Gopalakrishnan et al., Proc Natl Acad Sci U S A 2001 : Cdc18 is negatively controlled by cyclin dependent kinase (CDK) phosphorylation, but low level expression of a mutant form of Cdc18 lacking CDK phosphorylation sites ( Cdc18 ( CDK ) ) is not sufficient to induce rereplication
Gu et al., Mol Cancer Ther 2006 (Skin Neoplasms) : Silibinin caused decrease in E2F2 and E2F3 was accompanied by reduced levels of cyclin dependent kinases, cyclins, CDC25C , and mitogen activated protein kinases and Akt signaling and inhibition of cell proliferation
Singh et al., Clin Cancer Res 2009 (Prostatic Neoplasms) : Decreased levels of cyclin dependent kinases 2, 4, and 6, CDC2 , and cyclins D1, D3, E, and A were observed, indicating an inhibitory effect of silibinin on cell cycle progression
Gerber et al., Proc Natl Acad Sci U S A 1995 : We have investigated the role of Cdc37 in the regulation of the cyclin dependent protein kinase Cdc28
Elsasser et al., Mol Biol Cell 1996 : During purification of recombinant Cdc6 expressed in yeast, we found that Cdc6 interacts with the critical cell cycle, cyclin dependent protein kinase Cdc28. Cdc6 and Cdc28 can be coimmunoprecipitated from extracts, Cdc6 is retained on the Cdc28 binding matrix p13-agarose, and Cdc28 is retained on an affinity column charged with bacterially produced Cdc6
Amon et al., EMBO J 1997 : Cln-Cdc28 kinase activity at START is required to repress B-type cyclin-specific proteolysis
Charles et al., Curr Biol 1998 : We investigated the role of Cdc5 in the regulation of mitotic cyclin degradation
Cross et al., Mol Cell Biol 1998 : The enzymatic and biological activity of the mutant Cdc28p was essentially normally regulated by cyclin , and the mutants supported normal cell cycle progression and regulation
Edgington et al., Mol Cell Biol 1999 : A specific amino acid substitution in the cyclin dependent protein kinase Cdc28 was found to cause constitutive expression of most filamentous growth characteristics