◀ Back to IL15
IL12A — IL15
Text-mined interactions from Literome
Milano et al., Clin Exp Immunol 2002
(Leishmaniasis, Visceral) :
Since
IL-15 , in the presence of anti-IL-4 MoAb,
caused a further increase in
IL-12 production and led to a significant production of IFN-gamma, one of its indirect effects on Th1 cell activation could be due to the latter 's effect on Th2 cytokines such as IL-4
Derre et al., J Immunol 2002
(Melanoma) :
We show that
IL-12 induces the expression of NKG2-A and/or CD94 by CD8 ( + ) T cells in culture, and that this induction was
mediated neither by IFN-gamma nor by
IL-15
Strengell et al., J Immunol 2003
:
We have previously shown that
IL-15 and IL-21
induce the expression of IFN-gamma, T-bet,
IL-12R beta 2, and IL-18R genes both in NK and T cells
Croy et al., J Reprod Immunol 2003
:
Here, we review recent studies showing that
IL-15 is the critical cytokine controlling uNK cell differentiation and that uNK cells are
activated by either
IL-12 or IL-18 and by other factors when both IL-12 and IL-18 are genetically absent from implantation sites
Musikacharoen et al., Blood 2005
:
Interleukin-15 induces
IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling
Watkins et al., J Immunol 2007
(Carcinoma, Lewis Lung...) :
Analysis of tumor infiltrating macrophages and distal TAMs revealed that
IL-12 , both in vivo and in vitro,
induced a rapid ( < 90 min ) reduction of tumor supportive macrophage activities ( IL-10, MCP-1, migration inhibitory factor, and TGFbeta production ) and a concomitant increase in proinflammatory and proimmunogenic activities ( TNF-alpha,
IL-15 , and IL-18 production )
Haeberlein et al., Eur J Immunol 2010
(Leishmaniasis, Visceral) :
Here, we investigated whether
IL-15 or IL-18
mediate the activity of
IL-12 or function as independent activators of NK cells
Marshall et al., J Immunol 2010
(Arenaviridae Infections) :
IL-12 , IL-15, IL-18, and IFN-gamma were not individually required for sensitization to produce IFN-gamma, but
IL-15 was
required for upregulation of granzyme B
Ferret-Bernard et al., Vet Res 2011
:
The
IL-15 increases
IL-12 production by an amplifying feedback loop involving CD40
Kishida et al., Clin Dev Immunol 2012
(Hepatitis C, Chronic) :
IL-15 was increased at the end of induction therapy in both early virologic responders ( EAVRs ) and late virologic responders ( LAVRs ) ; CXCL-8, CXCL-10, and CCL-4 levels were significantly decreased ( P < 0.05 ) in EAVR but not in LAVR during NCT, and
IL-12 increased significantly ( P < 0.05 ) and CXCL-8 decreased significantly ( P < 0.05 ) after the end of NCT in EAVR but not in LAVR
Hegde et al., Cell Immunol 1995
(Neoplasms, Experimental) :
AK-5 tumor
induced expression of
interleukin-12 : role of
IL-12 in NK-mediated AK-5 regression
Wu et al., Eur J Immunol 1997
:
Among 16 cytokines tested, IL-2, IL-7 and
IL-15 markedly
induced IL-12Rbeta1 expression and
IL-12 binding on resting PBMC, whereas IL-1alpha and tumor necrosis factor-alpha had a minimal enhancing effect
Avice et al., J Immunol 1998
:
IL-15 promotes
IL-12 production by human monocytes via T cell dependent contact and may contribute to IL-12 mediated IFN-gamma secretion by CD4+ T cells in the absence of TCR ligation