◀ Back to IGF1
IGF1 — NEUROD4
Text-mined interactions from Literome
Brooker et al., J Neurosci Res 2000
:
Endogenous
IGF-1 regulates the
neuronal differentiation of adult stem cells
Lichtenwalner et al., J Neurosci Res 2006
(Body Weight...) :
In the current study, we used a selective model of growth hormone (GH) and plasma IGF-I deficiency to evaluate the
role of GH and
IGF-I in regulating cell proliferation, survival, and
neuronal differentiation in the adult dentate gyrus
Sanz et al., Dev Neurobiol 2008
(MAP Kinase Signaling System) :
The ovarian hormone estradiol modulates
neuronal differentiation and survival and these effects are in part
mediated by the interaction with
insulin-like growth factor-I (IGF-I)
Han et al., Mol Cell Neurosci 2008
:
Among them, insulin and insulin-like growth factor (IGF) family are found to promote the neuronal differentiation of NPCs. Akt activation has been indicated to be responsible for the
insulin/IGF-I induced
neuronal differentiation
Maucksch et al., Neuroscience 2013
:
Ectopic expression of
IGF-I in the normal adult rat brain significantly increased the number of doublecortin ( Dcx ) -positive cells and the extent of their migration into the striatum 4 and 8 weeks after AAV2-IGF-I injection but did not
promote neuronal differentiation
Eustache et al., Brain Res Dev Brain Res 1994
:
Although IGF-1 and IGF-2 had similar effects,
IGF-1 induced a more pronounced muscular differentiation and IGF-2
promoted neuronal differentiation
Kim et al., J Biol Chem 1997
:
Insulin-like growth factor-I (IGF-I) induces
neuronal differentiation in vitro ... We further examined the role of mitogen activated protein kinase activation in
IGF-I stimulated
neuronal differentiation using the mitogen activated protein kinase/ERK kinase inhibitor PD98059 ... Together these results suggest that activation of ERKs is essential for
IGF-I stimulated
neuronal differentiation