Gene interactions and pathways from curated databases and text-mining

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E2F1 — PDCD6

Text-mined interactions from Literome

Kaelin et al., Cancer Biol Ther 2003 (Neoplasms) : Activation of E2F target genes is sufficient to induce unscheduled cellular proliferation but, under certain circumstances, can also lead to programmed cell death ( apoptosis )
Pardee et al., Cell cycle (Georgetown, Tex.) 2004 : Furthermore, over expression of E2F-1 activates programmed cell death ( apoptosis ), a safeguarding signal of aberrant growth of cells that have become carcinogenic
Reddien et al., Genetics 2007 : DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans