Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — VEGFA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Cohen et al., Am J Physiol 1999 : VEGF stimulates tyrosine phosphorylation of beta-catenin and small-pore endothelial barrier dysfunction
Easwaran et al., Cancer Res 2003 (Adenocarcinoma...) : beta-Catenin regulates vascular endothelial growth factor expression in colon cancer ... Taken together, our observations indicate a close link between beta-catenin signaling and the regulation of VEGF-A expression in colon cancer
Orlandini et al., J Biol Chem 2003 : Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability
Ilan et al., Lab Invest 2003 (Cell Transformation, Neoplastic...) : Interestingly, sequestration of endogenous VEGF in EOMA cultures resulted in a dramatic decrease in nuclear beta-catenin and a reduction in CD1 levels, whereas addition of exogenous VEGF elicited increased nuclear beta-catenin localization and increased CD1 levels in HUVEC
Shao et al., J Biol Chem 2005 (Colonic Neoplasms...) : Moreover, PGE2 and mutated beta-catenin stimulated the transcription of cyclin D1 and vascular endothelial growth factor in a synergistic fashion
Ali et al., J Pharmacol Sci 2006 : The novel Src kinase inhibitor M475271 inhibits VEGF induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association ... The findings reveal pretreatment with M475271 significantly inhibits VEGF induced VE-cadherin and beta-catenin phosphorylation
Leung et al., J Biol Chem 2006 : Transfection of a stable form of beta-catenin ( S37A ) or the use of a glycogen synthase kinase 3beta inhibitor to stabilize beta-catenin induced VEGF synthesis, whereas small interfering RNA mediated down-regulation of beta-catenin did not, confirming that the effect was beta-catenin-specific
Doyle et al., J Cell Biochem 2009 : Differential role of beta-catenin in VEGF and histamine induced MMP-2 production in microvascular endothelial cells
Steindl-Kuscher et al., Invest Ophthalmol Vis Sci 2009 : VEGF , on the other hand, led to a reduction in cyclin D1 and to an increase in GSK 3beta and beta-catenin expression which was paralleled by an increase in RPE-specific differentiation markers
Maes et al., EMBO J 2010 : Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones
Yang et al., Invest Ophthalmol Vis Sci 2010 : In addition, the VEGF induced transcriptional activation of beta-catenin and uPAR expression were blocked by PEDF and by inhibitors of p38 and MEK
Yang et al., Exp Eye Res 2012 : We have shown previously that p38 inhibitors preserve endothelial barrier function and block VEGF induced GSK/beta-catenin signaling