Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — SMAD1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Schohl et al., Development 2002 (MAP Kinase Signaling System) : We found that the patterns of P-MAPK, P-Smad1 and P-Smad2 are indeed strongly dependent on beta-catenin at this stage
Chakladar et al., Biochem Biophys Res Commun 2005 : Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment
Han et al., Dev Cell 2006 : Further analysis revealed that independent of its role in anti-Smad signaling, Smad7 bound beta-catenin and induced beta-catenin degradation by recruiting an E3 ligase, Smurf2, to the Smad7/beta-catenin complex
Yang et al., Bone 2009 : Both activated or total nuclear Smad158 and Smad2 levels increase as they become confluent, and beta-catenin protein expression increases as 2T3 cells become confluent, reflecting a set of genes involved in early preosteoblast to osteoblast commitment, as observed in vitro and in vivo
Paige et al., PloS one 2010 : Finally, we show that Wnt/beta-catenin signaling is required for Smad1 activation by BMP4