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CASP9 — MAP3K1
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Gebauer et al., Int J Oncol 2000
(Adenocarcinoma...) :
Analysis of the defective apoptotic pathway in 2008/C13 cells indicates that these cells are deficient in the proteolytic
activation of
MEKK1 by
caspase-3
Villunger et al., J Immunol 2000
:
It has been reported that cross linking Abs to Fas trigger c-Jun N-terminal kinase (JNK) signaling via
caspase mediated activation of
MEKK1 ( JNK kinase kinase ), elevation of ceramide levels or by recruitment of death domain associated protein ( DAXX ) to Fas
McGuire et al., J Biol Chem 2001
(Carcinoma, Squamous Cell) :
Selective induction of
caspase dependent MEK cleavage and up-regulation of
MEKK-1
Schlesinger et al., J Biol Chem 2002
:
Here, we show that
caspase dependent cleavage of
MEKK1 relocalizes the protease generated 91-kDa kinase fragment from a particulate fraction to a soluble cytoplasmic fraction
Bild et al., Oncogene 2002
:
The mechanism for MEKK1 induced apoptosis involves
caspase mediated cleavage of
MEKK1 , releasing a pro-apoptotic 91 kDa kinase fragment that serves to further amplify caspase activation in a feedback loop ... MEKK1 induced apoptosis is amplified by blocking PI-3 kinase activation and overexpression of AKT blocked both
MEKK1 induced apoptosis and
caspase activation
Johnson et al., Cancer Metastasis Rev 2002
(Prostatic Neoplasms) :
Calcitriol induces PARP cleavage, increases the bax/bcl-2 ratio, reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs, P-Erk-1/2 ) and phosphorylated Akt ( P-Akt ), induces
caspase dependent MEK cleavage and up-regulation of
MEKK-1 , all potential markers of the apoptotic pathway
Oida et al., Mol Cancer Ther 2007
(Lung Neoplasms) :
Molecular analysis of Ad-mda7 treated H1299-dnI kappa B alpha tumors showed increased
MEKK1 cleavage and
activation of
caspase-3 compared with Ad-mda7 treated H1299-Neo tumors
Widmann et al., Mol Cell Biol 1998
:
Following activation by genotoxins,
MEKK1 was cleaved in a
caspase dependent manner into an active 91-kDa kinase fragment ... Expression of
MEKK1 stimulated DEVD directed
caspase activity and induced apoptosis
Deak et al., Proc Natl Acad Sci U S A 1998
:
Activation of both SAPK and
MEKK1 after Fas ligation is
prevented by both viral and chemical
caspase 3 inhibitors, which in contrast fail to block activation of SAPK by rapidly acting cell stresses