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BDNF — IL1B

Text-mined interactions from Literome

Kemi et al., Respir Res 2006 : COX-inhibitors ( indomethacin and NS-398 ) markedly decreased IL-1beta stimulated secretion of BDNF , but not IL-1beta stimulated NGF secretion
Rage et al., Neurochem Int 2006 : IL-1beta regulation of BDNF expression in rat cultured hypothalamic neurons depends on the presence of glial cells ... In the present study, we have shown that IL-1beta increased BDNF mRNA expression in hypothalamic neuron enriched cultures whereas it reduced this expression in mixed cultures, i.e. containing astrocytes and neurons ... Notably, we investigated whether IL-1beta affected BDNF expression in vitro either on hypothalamic mixed cultures or on neuron enriched cultures ... Indomethacin blocked both stimulatory and inhibitory IL-1beta effects on BDNF mRNA expression whereas picrotoxin ( a GABA ( A ) blocker ) or MK-801 ( a NMDA receptor blocker ) had no effect on BDNF mRNA levels
Jornot et al., Rhinology 2007 (Nasal Polyps) : On the other hand, TNFalpha, IL-1beta , and IFN-gamma did not affect DPP-IV activity but significantly increased the cellular expression and the basolateral secretion of BDNF
Purmessur et al., Arthritis Res Ther 2008 (Spinal Diseases) : In cultured human nucleus pulposus cells, stimulation with IL-1beta led to significant increases in NGF and BDNF gene expression ( P < 0.05 )
Gruber et al., Biotech Histochem 2012 (Low Back Pain) : Interleukin 1-beta upregulates brain derived neurotrophic factor , neurotrophin 3 and neuropilin 2 gene expression and NGF production in annulus cells