Maemura et al., J Biol Chem 2000
:
Furthermore, Period2 and Cryptochrome1, whose expression show a circadian oscillation in peripheral tissues, inhibit the PAI-1 promoter activation by the CLOCK : CLIF heterodimer
Maemura et al., Ann N Y Acad Sci 2001
(Myocardial Infarction) :
Furthermore, Period and Cryptochrome, which are negative regulators in the feedback loop of the biological clock, inhibited PAI-1 promoter activation by the CLOCK : CLIF heterodimer