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APOB — TLR4

Text-mined interactions from Literome

Xu et al., Circulation 2001 (Arteriosclerosis) : Moreover, upregulation of TLR-4 in macrophages by oxidized LDL suggests that TLR-4 may provide a potential pathophysiological link between lipids and infection/inflammation and atherosclerosis
Liu et al., Med Hypotheses 2008 (Atherosclerosis) : Moreover, TLR4 expression in macrophages is up-regulated by oxidized LDL , which suggests a potential mechanism for the synergistic effects of hypercholesterolemia and infection in acceleration of atherosclerosis
Geng et al., Mol Cell Biochem 2010 (Atherosclerosis) : The results showed that the expression of TLR4 increased in response to ox-LDL
Sun et al., Br J Pharmacol 2011 : These effects were inhibited by Sal B. Sal B also triggered PPAR? activation and promoted PPAR? nuclear translocation, attenuated ox-LDL induced up-regulation of TLR4 and myeloid differentiation primary-response protein 88 and inhibited the downstream p38-MAPK signalling cascade
Yu et al., Acta Biochim Biophys Sin (Shanghai) 2011 (Atherosclerosis) : The mTOR inhibitor rapamycin blocked mTOR phosphorylation and inhibited TLR4 expression induced by ox-LDL ... Inhibition of ox-LDL induced mTOR activation reduced TLR4 expression, and improved the impaired lipid efflux
Kannan et al., J Biol Chem 2012 : Oxidatively modified low density lipoprotein (LDL) inhibits TLR2 and TLR4 cytokine responses in human monocytes but not in macrophages