Varchetta et al., PloS one 2012
(MAP Kinase Signaling System) :
Here, we demonstrate that cross linking of Siglec-7 by a specific monoclonal antibody ( mAb ) induces a remarkably high production of IL-6, IL-1a, CCL4/MIP-1ß, IL-8 and TNF-a Warzocha et al., Eur Cytokine Netw 1995
(Second Messenger Systems) :
The biological effects of TNF and LT alpha homotrimers are mediated by p55 and p75 receptors, while the heteromeric complex of LT alpha/LT beta transduces its cellular signal via LT beta-R
Van Zee et al., J Exp Med 1994
:
A number of recent studies have demonstrated that cellular responses to tumor necrosis factor (TNF) mediated by the p55 and the p75 TNF receptors are distinct