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MST1 — TNF
Text-mined interactions from Literome
Avitsur et al., Brain Behav Immun 2006
(Orthomyxoviridae Infections) :
Interestingly,
MSP induced increase in IL-1,
TNF-alpha and IFN-gamma mRNA expression was evident in females, but not in males
Gunella et al., Br J Pharmacol 2006
(Pulmonary Fibrosis...) :
Besides inducing interleukin-1 beta (IL-1beta) and interleukin-10 (IL-10) production,
MSP triggers an enhanced
tumor necrosis factor-alpha release, especially in healthy and pulmonary fibrosis smokers
Ohtsubo et al., Biochem Biophys Res Commun 2008
:
Western blot analysis revealed that
TNF-alpha induced activation of caspase 3 and
Mst1 in a time- and dose dependent manner ...
TNF-alpha induced
Mst1 activation is almost completely prevented by pretreatment with Z-DEVD-FMK, a caspase 3 inhibitor ... Diphenyleneiodonium, an inhibitor of NADPH oxidase, and N-acetylcysteine, a potent antioxidant, also inhibited
TNF-alpha induced
activation of
Mst1 and caspase 3, as well as apoptosis
Tong et al., Inflamm Res 2011
(Arthritis, Rheumatoid) :
MSP markedly
inhibited expression of inflammatory cytokines ( IL-1ß,
TNF-a and IL-18 ), chemokines ( MIP-1, MCP-1 and RANTES ) and iNOS, NO, COX-2 and PGE ( 2 ) in RASF stimulated by LPS
Ruan et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012
:
Silencing of
MST1 expression by siRNA diminishes
TNF-a mediated human umbilical vein endothelial cell apoptosis by inhibiting the cascade effect of caspase-3