Gene interactions and pathways from curated databases and text-mining

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CD274 — TNF

Text-mined interactions from Literome

Mazanet et al., J Immunol 2002 (Inflammation) : B7-H1 is not expressed constitutively by ECs ; however, it is rapidly induced by IFN-gamma, and synergistically by IFN-gamma and TNF
Chen et al., Mol Immunol 2006 : Flow cytometric analysis revealed that B7-H1 but not B7-DC constitutively expresses on TECs, and the B7-H1 protein expression was profoundly up-regulated by the stimulation of TNF-alpha with a dose dependent manner
Kobayashi et al., J Rheumatol 2005 (Sjogren's Syndrome) : In vitro analysis using HSG cells revealed that PD-L1 was induced by interferon-gamma but not by tumor necrosis factor-alpha and IL-1beta
Nagamatsu et al., Hum Reprod 2009 : B7-H1 blockade on DSCs strongly enhanced T cell cytokine production ( IFN-gamma, TNF-alpha and IL-2 ), whereas B7-DC blockade had similar but more modest effects
Ji et al., Hepatology 2010 (Liver Diseases...) : These findings were confirmed in T cell-macrophage in vitro coculture in which B7-H1Ig diminished tumor necrosis factor-a/IL-6 levels in an IL-10 dependent manner
Ou et al., Scientific reports 2012 (Lupus Erythematosus, Systemic) : Exogenous TNF-a restored PD-L1 expression on lupus monocytes