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KIT — TFAP2A

Text-mined interactions from Literome

Braeuer et al., Semin Cancer Biol 2011 (Melanoma...) : AP-2a regulates the expression of c-KIT , MMP-2, VEGF, and the adhesion molecule MCAM/MUC18
Bar-Eli et al., J Cell Physiol 1997 (Disease Progression...) : The expression of c-KIT and other genes associated with malignant melanoma ( such as MCAM/MUC18 ) is highly regulated by the transcription factor AP-2
Huang et al., EMBO J 1998 (Lung Neoplasms...) : Transfection of wild-type AP-2 into c-KIT negative A375SM melanoma cells activated a c-KIT promoter-driven luciferase reporter gene, while expression of a dominant negative AP-2B in c-KIT positive Mel-501 cells inhibited its activation ... These results indicate that the expression of c-KIT is highly regulated by AP-2 and that enforced AP-2 expression suppresses tumorigenicity and metastatic potential of human melanoma cells, possibly through c-KIT transactivation and SCF induced apoptosis