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SERPINE1 — UTP18

Text-mined interactions from Literome

Bouchie et al., Arterioscler Thromb Vasc Biol 2000 : The ED ( 50 ) for the effect of UTP on PAI-1 expression was approximately 1 micromol/L, and its maximal effect occurred at 3 hours
Braun et al., J Mol Cell Cardiol 2010 : UTP increased rat CF migration 3-fold ( p < 0.001 ), proliferation by 30 % ( p < 0.05 ) and mRNA expression of profibrotic markers : alpha smooth muscle actin ( alpha-SMA ), plasminogen activator inhibitor-1 ( PAI-1 ), transforming growth factor beta, soluble ST2, interleukin-6 and monocyte chemoattractant protein-1 ( MCP-1 ) by 3.0-, 15-, 2.0-, 7.6-, 11-, and 6.1-fold, respectively ( p < 0.05 ). PAI-1 protein expression induced by UTP was dependent on protein kinase C ( PKC ) and extracellular signal regulated kinase ( ERK ), based on blockade by the PKC inhibitor Ro-31-8220 and the ERK inhibitor U0126, respectively. The rank order for enhanced expression of PAI-1 and alpha-SMA by nucleotides ( UTPgammaS > > UDPbetaS > > ATPgammaS ), the expression of P2Y2 receptors as the most abundantly expressed P2Y receptor in rat CFs and a blunted response to UTP in P2Y2 ( -/- ) mice all implicate P2Y2 as the predominant P2Y receptor that mediates nucleotide promoted profibrotic responses