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SERPINE1 — USF2

Text-mined interactions from Literome

Dimova et al., J Biol Chem 2006 (Anoxia...) : The transcription factor USF-2 was shown to be a negative regulator for rat PAI-1 expression, and therefore it was the aim of this study to evaluate the role of USF-2 for human PAI-1 expression ... We found in human hepatoma cells ( HepG2 ) that USF-2 induced human PAI-1 expression via two classical E-boxes and the hypoxia-responsive element ( HRE ) within the promoter ... Cotransfection of human or rat PAI-1 promoter luciferase constructs with expression vectors for wild-type USF-2 or USF-2 mutants in human HepG2 and rat H4IIE cells as well as in primary rat hepatocytes revealed that the effects of USF on PAI-1 expression depend on the cell type rather than the promoter context and that the USF-specific region domain of USF accounts for the observed cell type-specific effects
Olave et al., J Cell Biochem 2010 : Upstream stimulatory factor-2 mediates quercetin induced suppression of PAI-1 gene expression in human endothelial cells