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MAG — RHOA

Pathways - manually collected, often from reviews:

• Reactome Reaction: MAG → RHOA (indirect_complex)
• Reactome Reaction: MAG → RHOA (reaction) Yamashita et al., Nat Neurosci 2003

Text-mined interactions from Literome

Yamashita et al., J Cell Biol 2002 : MAG activates small GTPase RhoA , leading to retarded outgrowth when p75 ( NTR ) ) is present
Niederöst et al., J Neurosci 2002 : Nogo-A and myelin associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1 ... Furthermore, we show that the recently cloned receptor for Nogo-66 and MAG, NgR, is not necessary for either NiG- or MAG induced RhoA activation
Bandtlow et al., Exp Gerontol 2003 : Interestingly, elevated cAMP levels abrogated the Nogo-A and MAG mediated activation of RhoA and down regulation of Rac1 in adult neurons
Ceni et al., Neuron 2005 : In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis ( RIP ) of p75NTR and find that p75NTR cleavage is required for MAG induced RhoA activation and growth inhibition
Stiles et al., J Cell Sci 2013 : Mechanistic studies in N2a cells showed that LRP1 and p75NTR associate in a MAG dependent manner and that MAG mediated activation of RhoA may involve both LRP1 and p75NTR