Hua et al., Biochem Biophys Res Commun 2005
(Reperfusion Injury) :
Transfection of Ad5-dnMyD88 significantly inhibited I/R enhanced NFkappaB activity by 50 % and increased the levels of phospho-Akt by 35.6 % and BCL-2 by 81 %, respectively
Hellerbrand et al., Hepatology 1998
(Liver Cirrhosis, Experimental) :
Proteasome inhibitors, which block the degradation of IkappaB, and the Ad5IkappaB , which provides an exogenous nondegradable IkappaB, block the stimulation of NFkappaB activity by TNFalpha and IL-1beta in activated HSCs