Gene interactions and pathways from curated databases and text-mining

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DUSP1 — RELA

Text-mined interactions from Literome

Wang et al., J Biol Chem 2008 : Together, these results suggest that MKP-1 is a NF-kappaB mediated prosurvival effector in attenuating JNK mediated pro-apoptotic response ; NF-kappaB/MKP-1 mediated negative JNK regulation represents a potential therapeutic target for adjusting cell radiosensitivity
Bladh et al., Biochim Biophys Acta 2009 (MAP Kinase Signaling System) : However, TPA treatment alone resulted in much stronger MKP-1 expression in both GRwt and GRR488Q containing cells than that of dexamethasone suggesting that the inability of GRR488Q to inhibit TPA induced NF-kappaB activity did not involve a lack of MKP-1 expression
Wang et al., Mucosal Immunol 2010 : Induction of MKP-1 is blocked by inhibitors of nuclear factor (NF)-kappaB , but not of MAPK ... Thus, NF-kappaB dependent expression of MKP-1 may contribute, by desensitization of p38, to the rapid establishment of unresponsiveness to several TLR ligands in enterocytes