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CDC42 — RELA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RELA → CDC42 (increases, CDC42 Activity, RELA Activity)
  Evidence: Fibronectin-induced p65 nuclear translocation was inhibited by the expression of dominant negative Cdc42 in HUVECs but the effect was smaller than that exerted by Rac.

Text-mined interactions from Literome

Huttunen et al., J Biol Chem 1999 (Neuroblastoma) : In contrast, the activation of NF-kappaB is inhibited by dominant negative Ras but not Rac or Cdc42
Puls et al., J Cell Sci 1999 (Inflammation) : When expressed in fibroblasts, LMP1 stimulates Cdc42 dependent filopodia formation as well as JNK and NF(kappa)B activation
Cammarano et al., J Biol Chem 2001 : Here we show that although Dbl activation of NF kappa B requires Cdc42 , Rac, and Rho, the different GTPases activate NF kappa B by different mechanisms ... Whereas Rac stimulates the activity of the I kappa B kinase IKK beta, Cdc42 and Rho activate NF kappa B without activating either IKK alpha or IKK beta
Zhao et al., Biochem J 2002 : We also demonstrate that SP rapidly activates RhoA, Rac1 and Cdc42 and that co-expression of the dominant negative mutants of RhoA, Rac1 and Cdc42 in NK-1R cDNA transfected NCM460 cells significantly inhibits SP-induced NF-kappaB dependent gene expression
Grassl et al., Cell Microbiol 2003 (MAP Kinase Signaling System) : Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin
Chen et al., Biochem Biophys Res Commun 2004 : These results indicate that fMLP stimulates three members of the Rho family of GTPases Rac1, Cdc42, and RhoA activity in monocytes, and that Rac1 and RhoA, but not Cdc42 , is required for fMLP induced NF-kappaB activation
Perona et al., Genes Dev 1997 : The human RhoA, CDC42 , and Rac-1 proteins efficiently induce the transcriptional activity of nuclear factor kappaB (NF-kappaB) by a mechanism that involves phosphorylation of Ikappa Balpha and translocation of p50/p50 and p50/p65 dimers to the nucleus, but independent of the Ras GTPase and the Raf-1 kinase ... In contrast, activation of NF-kappaB by UV light was not affected by Rho, CDC42 , or Rac-1 dominant negative mutants
Montaner et al., J Biol Chem 1998 : Finally, mutants of RhoA and Cdc42Hs , but not that of Rac1, inhibited the activation of NF-kappaB by Ost