Gene interactions and pathways from curated databases and text-mining

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DIAPH1 — PXN

Pathways - manually collected, often from reviews:

  • BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) (actin filament polymerization, activates)
  • BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, activates)