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AGTR1 — NOS1
Text-mined interactions from Literome
Roczniak et al., J Am Soc Nephrol 1999
(Disease Models, Animal) :
Losartan treatment was used to determine the role of angiotensin II ( AngII )
AT1 receptors in the inhibition of nNOS expression in 5/6 Nx. Losartan had no effect on the decreased expression of nNOS in the inner medulla, but partially
increased nNOS protein expression in the cortex of 5/6 Nx rats
Qadri et al., Jpn J Pharmacol 2001
:
Angiotensin converting enzyme inhibitors and
AT1-receptor antagonist
restore nitric oxide synthase (NOS) activity and neuronal NOS expression in the adrenal glands of spontaneously hypertensive rats
Kiss et al., Endocr Regul 2001
:
Changes in angiotensin
AT1 receptor mRNA levels in the rat brain after immobilization stress and inhibition of central
nitric oxide synthase
Andersen et al., Am J Physiol Regul Integr Comp Physiol 2002
:
Volume expansion increased arterial pressure significantly in all series involving this procedure, most pronounced during combined
AT(1) blockade and
NOS inhibition ( 21 +/- 4 mmHg ) ... Volume expansion during AT(1) blockade increased GFR ( +30 % ), less so during combined
AT(1) blockade and
NOS inhibition ( +13 % ), but it did not increase GFR significantly ( P = 0.07 ) during NOS inhibition alone
Wang et al., Physiol Res 2007
:
Role of brain angiotensin
AT1 receptor in the carbachol induced natriuresis and expression of
nNOS in the locus coeruleus and proximal convoluted tubule
Suzuki et al., Endocrinology 2006
(Hypertrophy) :
Activation of endothelial
nitric oxide synthase by the
angiotensin II type 1 receptor
Dong et al., J Pharmacol Exp Ther 2011
(Hypertension...) :
High-salt loading in SHRSPs caused the reduction of cerebral blood flow (CBF), cerebral hypoxia, white matter lesions, glial activation,
AT1 receptor up-regulation, endothelial nitric-oxide synthase (eNOS) uncoupling, inducible
nitric-oxide synthase induction , and nitroxidative stress
Sharma et al., Cardiovasc Res 2011
(Chronic Disease...) :
Identifying this crucial
nNOS/CAPON interaction
regulated by
AT(1) receptors may provide an important potential therapeutic target in CHF
Sharma et al., Am J Physiol Cell Physiol 2012
:
Specific inhibition of
nNOS , using antisense,
caused an increase in
AT(1)R expression while overexpression of nNOS, using adenoviral gene transfer ( Ad.nNOS ), caused an inhibition of AT(1)R expression in NG108 cells
Nakayama et al., Blood Press Suppl 1994
:
Angiotensin II type 1 receptor mediated inhibition of cytokine stimulated inducible
nitric oxide synthase expression in vascular smooth muscle cells