◀ Back to MAPK11
MAPK11 — OLR1
Text-mined interactions from Literome
Li et al., Circulation 2000
:
Activation of mitogen activated protein kinase ( MAPK ) may play a critical role in signal transduction in ox-LDL mediated alteration in MCP-1 expression, since antisense
LOX-1 , but not the sense LOX-1, completely
inhibited the ox-LDL induced
MAPK activation
Iwai-Kanai et al., Circulation 2001
(Heart Failure) :
Antioxidant catalase also blocked
LOX-1 induced apoptosis as well as activation of p38
MAPK ... These findings demonstrate that
LOX-1 expression in cardiac myocytes is induced by neurohormonal factors activated in heart failure and that LOX-1 dependent apoptosis in these cells
requires p38
MAPK , a component of oxidant stress-sensitive signaling pathways
Kobayashi et al., Hypertension 2005
(Glomerulosclerosis, Focal Segmental...) :
Eplerenone shows renoprotective effect by reducing
LOX-1 mediated adhesion molecule,
PKCepsilon-MAPK-p90RSK , and Rho-kinase pathway