Agouni et al., Carcinogenesis 2007
(Carcinoma, Renal Cell...) :
PTHrP activates ILK which then acts as a phosphoinositide dependent kinase ( PDK)-2 or a facilitator protein to phosphorylate Akt at S473
Ardura et al., American journal of physiology. Renal physiology 2008
(Fibrosis...) :
In vitro, PTHrP- ( 1-36 ) increased ( maximal 2-fold vs. basal, at 100 nM ) alpha-SMA and ILK protein expression and decreased E-cadherin protein levels in renal tubuloepithelial mouse cortical tubule and normal rat kidney (NRK) 52E cells