◀ Back to ILK
ILK — LIMS2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Integrin-linked kinase signaling:
ILK (ILK)
→
ILK/PINCH2/alpha parvin complex (ILK-LIMS2-PARVA)
(modification, collaborate)
Tu et al., Mol Cell Biol 1999, Li et al., J Cell Sci 1999, Zhang et al., J Biol Chem 2002*, Zhang et al., J Cell Sci 2002*, Fukuda et al., J Biol Chem 2003, Stanchi et al., J Cell Sci 2005*, Yang et al., J Biol Chem 2009*, Chiswell et al., J Struct Biol 2010*
Evidence: physical interaction
-
NCI Pathway Database Integrin-linked kinase signaling:
ILK (ILK)
→
PINCH2 (LIMS2)
(modification, collaborate)
Tu et al., Mol Cell Biol 1999, Li et al., J Cell Sci 1999, Zhang et al., J Biol Chem 2002*, Zhang et al., J Cell Sci 2002*, Fukuda et al., J Biol Chem 2003, Stanchi et al., J Cell Sci 2005*, Yang et al., J Biol Chem 2009*, Chiswell et al., J Struct Biol 2010*
Evidence: physical interaction
-
NCI Pathway Database Integrin-linked kinase signaling:
PINCH1 (LIMS1)
→
ILK/PINCH2/alpha parvin complex (ILK-LIMS2-PARVA)
(modification, collaborate)
Tu et al., Mol Cell Biol 1999, Li et al., J Cell Sci 1999, Zhang et al., J Biol Chem 2002*, Zhang et al., J Cell Sci 2002*, Fukuda et al., J Biol Chem 2003, Stanchi et al., J Cell Sci 2005*, Yang et al., J Biol Chem 2009*, Chiswell et al., J Struct Biol 2010*
Evidence: physical interaction
-
NCI Pathway Database Integrin-linked kinase signaling:
ILK/PINCH2/alpha parvin complex (ILK-LIMS2-PARVA)
→
alpha parvin (PARVA)
(modification, collaborate)
Tu et al., Mol Cell Biol 1999, Li et al., J Cell Sci 1999, Zhang et al., J Biol Chem 2002*, Zhang et al., J Cell Sci 2002*, Fukuda et al., J Biol Chem 2003, Stanchi et al., J Cell Sci 2005*, Yang et al., J Biol Chem 2009*, Chiswell et al., J Struct Biol 2010*
Evidence: physical interaction
-
NCI Pathway Database Integrin-linked kinase signaling:
ILK/PINCH2/alpha parvin complex (ILK-LIMS2-PARVA)
→
ILK/PINCH1/alpha parvin complex (ILK-LIMS1-PARVA)
(modification, collaborate)
Tu et al., Mol Cell Biol 1999, Li et al., J Cell Sci 1999, Zhang et al., J Biol Chem 2002*, Zhang et al., J Cell Sci 2002*, Fukuda et al., J Biol Chem 2003, Stanchi et al., J Cell Sci 2005*, Yang et al., J Biol Chem 2009*, Chiswell et al., J Struct Biol 2010*
Evidence: physical interaction
-
NCI Pathway Database Integrin-linked kinase signaling:
ILK/PINCH2/alpha parvin complex (ILK-LIMS2-PARVA)
→
PINCH2 (LIMS2)
(modification, collaborate)
Tu et al., Mol Cell Biol 1999, Li et al., J Cell Sci 1999, Zhang et al., J Biol Chem 2002*, Zhang et al., J Cell Sci 2002*, Fukuda et al., J Biol Chem 2003, Stanchi et al., J Cell Sci 2005*, Yang et al., J Biol Chem 2009*, Chiswell et al., J Struct Biol 2010*
Evidence: physical interaction
-
NCI Pathway Database Integrin-linked kinase signaling:
ILK/PINCH1/alpha parvin complex (ILK-LIMS1-PARVA)
→
PINCH2 (LIMS2)
(modification, collaborate)
Tu et al., Mol Cell Biol 1999, Li et al., J Cell Sci 1999, Zhang et al., J Biol Chem 2002*, Zhang et al., J Cell Sci 2002*, Fukuda et al., J Biol Chem 2003, Stanchi et al., J Cell Sci 2005*, Yang et al., J Biol Chem 2009*, Chiswell et al., J Struct Biol 2010*
Evidence: physical interaction
-
Reactome Reaction:
ILK
→
LIMS2
(direct_complex)
Tu et al., J Cell Biol 2001*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ILK
—
LIMS2
(physical association, affinity chromatography technology)
Varjosalo et al., Nat Methods 2013
-
IRef Biogrid Interaction:
ILK
—
LIMS2
(physical association, affinity chromatography technology)
Zhang et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
ILK
—
LIMS2
(in vitro)
Zhang et al., J Biol Chem 2002*
-
IRef Hprd Interaction:
ILK
—
LIMS2
(in vivo)
Zhang et al., J Biol Chem 2002*
-
IRef Intact Interaction:
Complex of 58 proteins
(association, tandem affinity purification)
Varjosalo et al., Nat Methods 2013
-
IRef Ophid Interaction:
ILK
—
LIMS2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
ILK
—
LIMS2
(aggregation, confirmational text mining)
Zhang et al., J Biol Chem 2002*
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2002
:
Overexpression of
PINCH-2 significantly
inhibited the
PINCH-1-ILK interaction and reduced cell spreading and migration ... These results identify a novel nuclear and focal adhesion protein that associates with ILK and reveals an important
role of
PINCH-2 in the regulation of the
PINCH-1-ILK interaction, cell shape change, and migration
Fukuda et al., J Biol Chem 2003
:
Finally, increased expression of
PINCH-2 , an ILK binding protein that is structurally related to PINCH-1,
prevented the down-regulation of
ILK and alpha-parvin induced by the loss of PINCH-1 but failed to restore the survival signaling or cell shape modulation