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IL1B — SPI1

Text-mined interactions from Literome

Toda et al., J Immunol 2002 : EMSAs using THP-1 cell nuclear extracts indicated that IL-1beta significantly induced Spi-1 binding to its target site within the IL1B promoter that was maximal at 1 h after stimulation, correlating with the kinetics of IL-1beta induction ... We conclude that the IL1B promoter is an IL-1beta-responsive sequence as a result of its ability to bind Spi-1 in response to IL-1beta
Yang et al., Biochem Biophys Res Commun 2002 : Dual regulatory role of human cytomegalovirus immediate-early protein in IL1B transcription is dependent upon Spi-1/PU.1 ... We now show a distinct mechanism by which IE1 and IE2 mediate both weak Spi-1 independent and vigorous Spi-1 dependent IL1B transcription from the -59 to +12 IL1B core promoter
Kominato et al., Mol Cell Biol 1995 : Finally, the IL1B promoter, which is inactive in Spi-1-deficient HeLa cells, is activated in these cells by cotransfection with a Spi-1 expression vector