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IGFBP3 — IL1B

Text-mined interactions from Literome

Liu et al., Endocr J 1999 : Both IL-1beta and TNF-alpha inhibited IGFBP-3 ( 42/38 KDa species ) production in a concentration dependent manner judged by Western ligand blot
Wang et al., Endocrinology 1995 : IL-1 beta increased the average transcription rate of IGFBP-3 by 3.3-fold ... The immunoblot of cell conditioned media showed that the basal level of IGFBP-3 protein was low and IL-1 beta caused a dose dependent increase in the production of IGFBP-3 ... The addition of cycloheximide markedly inhibited IL-1 beta induced IGFBP-3 mRNA levels ... In conclusion, IL-1 beta inhibits IGF-I but increases IGFBP-3 expression in Leydig cells, and this may contribute to the inhibitory effects of IL-1 beta on Leydig cell steroidogenesis
Rosen et al., Endocrine 1997 : In all cultures of marrow from postmenopausal women, IL-1 beta suppressed IGFBP-3 secretion to either undetectable levels or levels between 11 % and 35 % of control