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CSF3 — IL17A

Text-mined interactions from Literome

Schwarzenberger et al., J Immunol 2000 : In this study, we show that IL-17 mediated granulopoiesis requires G-CSF release and the presence or induction of the transmembrane form of stem cell factor (SCF) for optimal granulopoiesis
Ye et al., J Exp Med 2001 (Klebsiella Infections) : We hypothesized that IL-17 receptor (IL-17R) signaling is critical for G-CSF and CXC chemokine production and lung host defenses ... Thus, IL-17R signaling is critical for optimal production of G-CSF and MIP-2 and local control of pulmonary K. pneumoniae infection
Pan et al., J Immunol 2001 (Eosinophilia...) : In addition, IL-17E induces G-CSF production in vitro and mIL-17E-transgenic mice had increased serum G-CSF and exhibit neutrophilia, a property shared by IL-17
Jones et al., Am J Respir Cell Mol Biol 2002 : Secretion of IL-8, Groalpha, and G-CSF in response to IL-17 was measured in HBEC cell culture supernatants by enzyme linked immunosorbent assay ... In addition, IL-17 was found to synergistically enhance TNF-alpha induced production of IL-8, Groalpha, and G-CSF
Numasaki et al., Immunol Lett 2004 : Regulatory roles of IL-17 and IL-17F in G-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha ... We therefore investigated the effects of IL-17 and IL-17F on the regulation of G-CSF production by lung microvascular endothelial cells ( LMVECs )
McAllister et al., J Immunol 2005 (Cystic Fibrosis...) : IL-17A and IL-17F were potent inducers of growth related oncogene-alpha and G-CSF in HBE cells, and significant synergism was observed with TNF-alpha largely due to signaling via TNFRI
Ley et al., Immunol Res 2006 : IL-17A produced by Tn cells regulates the production of G-CSF , which in turn promotes the proliferation of promyelocytes and maturation of neutrophils
Witowski et al., Kidney Int 2007 : Tumor necrosis factor alpha synergistically amplified IL-17A induced G-CSF production by enhanced NF-kappaB activation and through stabilization of G-CSF mRNA
Smith et al., J Immunol 2008 : We conclude that IL-17A regulates blood neutrophil counts by inducing G-CSF production mainly in nonhemopoietic cells
Mei et al., J Clin Invest 2012 : Conversely, G-CSF was required for Cxcl5 dependent regulation of neutrophil homeostasis, and inhibition of IL-17A reduced plasma G-CSF concentrations and marrow neutrophil numbers in both Cxcl5 ( -/- ) and Cxcr2 ( -/- ) mice
Chung et al., Nat Med 2013 (Colorectal Neoplasms...) : Tumor infiltrating T helper type 17 ( TH17 ) cells and interleukin-17 (IL-17) induced the expression of granulocyte colony stimulating factor ( G-CSF ) through nuclear factor ?B ( NF-?B ) and extracellular related kinase (ERK) signaling, leading to immature myeloid-cell mobilization and recruitment into the tumor microenvironment
Cai et al., Immunol Lett 1998 : Stability studies revealed that IL-17 stabilized G-CSF mRNA levels, with a t1/2 of 4 h, compared to a t1/2 of less than 2 h in medium or LPS treated cells ... Induction of G-CSF expression in 3T3 cells by IL-17 did not appear to require tyrosine kinase activation or de novo protein synthesis ... These studies indicate that post-transcriptional mechanisms play an important role in IL-17 induced G-CSF expression in fibroblasts and suggest that IL-17 may be useful for further delineating mechanisms of G-CSF gene regulation