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FLNA — PAK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Vadlamudi et al., Nat Cell Biol 2002
:
The FLNa binding site in Pak1 is localized between amino acids 52 and 132 in the conserved Cdc42/Rac interacting ( CRIB ) domain ; accordingly,
FLNa binding to the CRIB domain
stimulates Pak1 kinase activity ... Our results indicate that
FLNa may be essential for Pak1 induced cytoskeletal reorganization and that the two-way regulatory interaction between Pak1 and FLNa may
contribute to the local stimulation of
Pak1 activity and its targets in cytoskeletal structures
Maceyka et al., Mol Cell Biol 2008
:
SphK1 was required for heregulin induced migration, lamellipodia formation,
activation of
PAK1 , and subsequent
FLNa phosphorylation