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EPHB2 — EPX
Text-mined interactions from Literome
Mason et al., J Biol Chem 2000
:
EPO dependent activation of
ERK1/2 and protein kinase B (PKB)/Akt was examined utilizing a panel of EPO-R deletion mutants
Zhang et al., Exp Hematol 2001
:
In contrast,
EPO dependent p70 S6K phosphorylation/activation, as well as IRS-2 and
ERK1/2 phosphorylation, were minimal or absent in cells transfected with EPO-R-131 or EPO-R-221
Arai et al., J Biol Chem 2001
:
Overexpression of Lyn induced constitutive phosphorylation of CrkL and activation of Erk, whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the
Epo induced phosphorylation of CrkL and
activation of
Erk
Chen et al., J Biol Chem 2001
:
The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 blocked Myc up-regulation in a concentration dependent manner but had no effect on the
Epo induced phosphorylation of
ERK1 and ERK2
Kolonics et al., Haematologia (Budap) 2001
(Acute Disease...) :
In UCBMNC and NBMMNC,
Epo and GM-CSF
induced the activation of STAT-5 DNA binding and
ERK 1/2 activation ( n = 6 )
Lee et al., Biochem Biophys Res Commun 2004
:
Conversely, treatment with anti-EPO and EPO receptor antibodies also reduced
EPO induced
ERK ( 2 ) and NF-kappaB activation
Bose et al., Am J Physiol Cell Physiol 2008
(Pancreatic Neoplasms) :
Taken together, our results indicate that AR42J cells express EPOR and that the
activation of both
ERK1/2 and JNK1/2 by
EPO is essential in regulating proliferation and the cell cycle
Talbot et al., PloS one 2011
(MAP Kinase Signaling System...) :
This inhibition spares metabolic function but impedes
EPO induced
ERK signaling and disturbs a newly identified ERK-aconitase physical interaction
Dale et al., J Neurosci 2012
:
EPO increased phosphorylation ( and presumed activation ) of
ERK ( 1.6-fold vs controls ; p < 0.05 ) in phrenic motor neurons ; EPO also increased pAkt ( 1.6-fold vs controls ; p < 0.05 )
Jun et al., J Cell Physiol 2013
:
In this study, we aimed to investigate the influence of
EPO induced
ERK signaling on the regulation of GATA-4 protein action ...
EPO induced
ERK activation further increased the association of GATA-4 with p300 ... Taken together, these results indicated that
EPO induced
ERK signaling activation increased GATA-4 phosphorylation and acetylation, partly via increase in the association between GATA-4 and p300, and these processes required the phosphorylation of GATA-4 at Ser-261 residue
Itoh et al., J Mol Cell Cardiol 2012
(Diabetes Mellitus, Type 2...) :
Levels of calcineurin activity and
EPO induced phosphorylation of Akt and
ERK were similar in GK and Wistar, though cytosolic HSP70 level was 50 % lower and mitochondrial HSP60 level was 60 % higher in GK
Jun et al., Biol Pharm Bull 2013
:
Under hypoxic condition without reperfusion,
EPO induced
ERK activation was associated with post-translational modification of GATA-4, mediated by enhancement of phosphorylation of GATA-4 at Ser-105
Barber et al., Blood 1997
:
In addition,
EPO , IL-2, and IL-15
activated Raf1 and
ERK2 , demonstrating that the Raf1/MEK/MAP kinase pathway was activated