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APC — EPHB2

Text-mined interactions from Literome

Huang et al., Sheng Li Xue Bao 2003 (Anoxia) : APC inhibited the over activation of both ERK ( 1/2 ) and p38 during the following sustained anoxia
da Silva et al., Anesthesiology 2004 (Reperfusion Injury) : IPC but not APC markedly activated ERK1/2 and p38 MAPK, which were abrogated by coadministration of the specific blockers ... Conversely, IPC and APC enhanced ERK1/2 activity after ischemia-reperfusion as compared to nonpreconditioned hearts, and IPC in addition enhanced p38 MAPK activity
Park et al., J Cell Sci 2006 (MAP Kinase Signaling System) : APC inhibits ERK pathway activation and cellular proliferation induced by RAS ... ERK activity was increased by Cre-virus induced Apc knockout in primary Apc ( flox/flox ) mouse embryonic fibroblasts, indicating that APC inhibits ERK activity ... The GTP loading and the protein level of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression, indicating that APC regulates RAS induced ERK activation at least partly by reduction of the RAS protein level
O'Brien et al., Arterioscler Thromb Vasc Biol 2007 : Using siRNA, we found that the effect of APC on the EGR-1/ERK signaling required for TRAIL inhibition was dependent on the S1P1 receptor and S1P1 kinase
Xue et al., J Cell Mol Med 2009 : APC dose-dependently stimulated phosphorylated ( P ) -ERK2 and inhibited P-p38
Gramling et al., Exp Cell Res 2010 (Breast Neoplasms...) : Intracellularly, APC activates ERK , Akt, and NFkappaB, but not the JNK pathway to promote MDA-MB-231 cell motility
Maniatis et al., Crit Care 2010 (Ventilator-Induced Lung Injury) : The effect of APC on ERK signaling downstream of the thrombin receptor was tested on A549 human lung epithelial cells by immunoblotting
Caro-Gonzalez et al., J Cell Sci 2012 : Mitogen activated protein kinase ( MAPK/ERK ) regulates adenomatous polyposis coli during growth-factor induced cell extension