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CCND1 — GSK3B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCND1 → GSK3B (increases, GSK3B Translocation)
  Evidence: Cyclin D1 is a rather unstable molecule that is transported from the nucleus to the cytoplasm where it is targeted by the SCF UBIQUITIN LIGASE for proteolysis.Nuclear export is mediated by glycogen synthase kinase 3-? (GSK-3?), a kinase that is inhibited by the RAS/PI3K/AKT PATHWAY
• OpenBEL Selventa BEL large corpus: CCND1 → GSK3B (decreases, CCND1 Activity)
  Evidence: AKTactivates cell proliferation by inactivating p27 (Fujita et al., 2002) and inhibiting glycogen synthase kinase 3 (GSK3)- mediated Myc and cyclin D1 inhibition (Vivanco and Sawyers, 2002).
• KEGG Cell cycle: GSK3B → CCND1/CCND2/CCND3 (protein-protein, inhibition)
• WikiPathways ErbB Signaling Pathway: GSK3B → MYC/CCND1 (inhibition)
• WikiPathways Copper homeostasis: GSK3B → CCND1 (inhibition)

Text-mined interactions from Literome

Alt et al., Genes Dev 2000 (Cell Transformation, Neoplastic) : GSK-3beta dependent phosphorylation of cyclin D1 at Thr-286 promotes the nuclear-to-cytoplasmic redistribution of cyclin D1 during S phase of the cell cycle, but how phosphorylation regulates redistribution has not been resolved
Shin et al., Exp Mol Med 2002 : Since GSK-3beta is involved in cyclin D1 proteolysis in response to mitogenic stimulation, PLCgamma1 mediated GSK-3beta phosphorylation may function as a regulation of cyclin D1 accumulation in PLCgamma1 overexpressing cells
Lu et al., Cancer Res 2003 (Esophageal Neoplasms) : Glycogen synthase kinase-3beta dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1 dependent cyclin D1 nuclear export at the G ( 1 ) -S boundary
Bai et al., J Biol Chem 2004 : Our results demonstrate that MPP ( + ) induces cell cycle arrest independently of its mitochondrial toxicity or the p53 status of the target cells, but rather through the proteasome- and phosphatidylinositol 3-Akt-glycogen synthase kinase-3beta dependent cyclin D1 degradation
Farías et al., Neurobiol Dis 2004 : M1 mAChR activation inhibits glycogen-synthase-kinase-3beta ( GSK-3beta ) activity, stabilizes cytoplasmic and nuclear beta-catenin, and induces the expression of the Wnt target genes engrailed and cyclin-D1 , reverting the switch off of the Wnt pathway caused by Abeta-toxicity
Dong et al., Cancer Res 2005 (Breast Neoplasms) : Rapamycin treatment leads to an increase in the kinase activity of glycogen synthase kinase 3beta ( GSK3beta ), a known regulator of cyclin D1 proteolysis ... Rapamycin induced down-regulation of cyclin D1 is inhibited by the GSK3beta inhibitors lithium chloride, SB216763, and SB415286
Mori et al., Exp Cell Res 2005 (Carcinoma, Squamous Cell...) : Depletion of endogenous GSK-3beta by RNA interference also attenuated the effect of DIF-1 on cyclin D1 degradation
Cao et al., Cell Res 2006 (Ovarian Neoplasms) : Overexpressing constitutively active form of GSK-3beta induced entry into the S phase, increased cyclin D1 expression and facilitated the proliferation of ovarian cancer cells
Takahashi-Yanaga et al., J Biol Chem 2006 : Involvement of GSK-3beta and DYRK1B in differentiation inducing factor-3 induced phosphorylation of cyclin D1 in HeLa cells ... Depletion of endogenous GSK-3beta and dual-specificity tyrosine phosphorylation regulated kinase 1B ( DYRK1B ) by RNA interference attenuated the DIF-3 induced cyclin D1 phosphorylation and degradation
Singh et al., International journal of biological sciences 2007 : Suppression of GSK-3beta by SB216763 ( 100 nM ) increases CREB phosphorylation, cyclin D1 and fibronectin levels
Li et al., Sheng Li Xue Bao 2007 (Adenocarcinoma...) : Further, the expression of cyclin D1 was down-regulated by GSK3beta
Frederick et al., Glia 2007 (MAP Kinase Signaling System) : Consistent with a known role for GSK-3beta in cyclin D1 degradation, we show that proteasome inhibition in OPs exposed to FGF-2 increased cyclin D1 levels, equivalent to levels seen in IGF-I/FGF-2 treated cells
Zhu et al., Proc Natl Acad Sci U S A 2007 (Uterine Neoplasms) : This cyclin D1 nuclear accumulation results from the inhibition of glycogen synthase kinase 3beta ( GSK3beta ) activity caused by an inhibitory phosphorylation by protein kinase B
Ha et al., J Biol Chem 2007 : Inhibitory Ser-9 phosphorylation of glycogen synthase kinase 3beta ( GSK3beta ) by Akt prevented proteasome mediated cyclin D1 degradation and induced cell cycle progress in LeTx intoxicated THP-1 cells
Takahashi-Yanaga et al., Cell Signal 2008 (Neoplasms) : GSK-3beta regulates cyclin D1 expression : a new target for chemotherapy
Yoshikawa et al., Naunyn Schmiedebergs Arch Pharmacol 2008 (Melanoma, Experimental) : In conclusion, this study demonstrated that cordycepin inhibits the proliferation of B16-BL6 cells by stimulating adenosine A3 receptors followed by the Wnt signaling pathway, including GSK-3beta activation and cyclin D1 inhibition
Lin et al., Arch Biochem Biophys 2008 : Advanced glycation end-product inhibited cell proliferation and protein expression of beta-catenin and cyclin D1 are dependent on glycogen synthase kinase 3beta in LLC-PK1 cells ... AGE inhibited beta-catenin and cyclin D1 protein expression are dependent on GSK3beta
Larabee et al., Infect Immun 2008 : GSK-3beta inhibitors prevented declines in cellular levels of cyclin D1 and c-Jun following treatment of macrophages with ET
Pontano et al., Mol Cell Biol 2008 (Genomic Instability) : Double-strand break dependent cyclin D1 degradation requires ATM and GSK3beta , which in turn mediate cyclin D1 phosphorylation
Juhlin et al., Int J Oncol 2009 (Adenoma...) : The loss of APC and GSK3-beta did not lead to augmentation of the Wnt target protein cyclin D1 or the Wnt oncoprotein beta-catenin
Li et al., Int J Cancer 2010 (Brain Neoplasms...) : These findings suggest that GSK-3beta is a differentiation fate determinant, and shed new lights on the mechanism by which GSK-3beta regulates cyclin D1 degradation and cellular differentiation in gliomas
Shimura et al., Oncogene 2010 (Neoplasms) : Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta mediated cyclin D1 overexpression
Diehl et al., Genes Dev 1998 : Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization