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Auyeung et al., Int J Mol Med 2009
(Carcinoma, Hepatocellular...) :
AST also caused caspase activation, poly ( ADP-ribose ) polymerase ( PARP ) cleavage, nuclear chromatin condensation, with downregulation of the anti-apoptotic proteins bcl-2 and bcl-xL and decreased nuclear factor-kappa B (NF-kappaB)/DNA binding activity
Lee et al., Food Chem Toxicol 2011
(MPTP Poisoning) :
Furthermore, AST is able to enhance the expression of Bcl-2 protein but reduce the expression of a-synuclein and Bax, and suppress the cleavage of caspase-3 Li et al., Molecular vision 2013
:
AST inhibited expression of H2O2 induced cleaved caspase-3 protein