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CASP14 — H2AFX
Text-mined interactions from Literome
Lu et al., Mol Cell 2006
:
Taken together, these data indicated that
H2AX phosphorylation is
required for DNA ladder formation, but not for the activation of
caspase-3 ; and the JNK/H2AX pathway cooperates with the caspase-3/CAD pathway resulting in cellular apoptosis
Zhang et al., Oncol Rep 2010
(Carcinoma, Non-Small-Cell Lung...) :
We also showed that roscovitine induced an enhanced expression of
gamma-H2AX , which was
blocked by
caspase-3 inhibition, suggesting that p21Waf1/Cip1 cleavage may interfere with DNA repair, leading to increased frequency of double strand breaks ( DSBs ) and enhanced apoptosis
Martin et al., Curr Cancer Drug Targets 2011
(Breast Neoplasms...) :
Follow-up analysis of caspase activity and
caspase dependent phosphorylation of
histone H2AX demonstrated that the silencing of MAP3K7 enhanced CPT associated apoptosis