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INS — WNT3A

Text-mined interactions from Literome

Hooper et al., J Neurochem 2011 : Following a conservative correction ( Bonferroni ) for multiple testing, seven genes were identified to be differentially expressed from controls ; four of these genes were regulated by insulin and three genes were regulated by both insulin and Wnt3a
Thieme et al., Mol Cell Endocrinol 2012 (Diabetes Mellitus, Experimental...) : Insulin induced Wnt3a , Wnt4 and Brachyury expression in a temporal- and stage-specific pattern ... Only blastocysts cultured with insulin reached the Wnt3a, Wnt4 and Brachyury expression levels of stage 2 in vivo blastocysts, indicating that insulin is required for Wnt3a , Wnt4 and Brachyury expression during gastrulation ... Insulin induced Wnt3a and Wnt4 expression preceded Brachyury ... Involvement of insulin in embryonic Wnt3a expression was further shown in vivo with Wnt3a expression being notably down regulated in stage 2 blastocysts from rabbits with type 1 diabetes
Gui et al., J Cell Biochem 2013 : Wnt3a also promoted NIT-1 cell proliferation, inhibited cytokine induced beta-cell apoptosis, and increased insulin secretion