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TBK1 — TRAF6

Pathways - manually collected, often from reviews:

• Reactome Reaction: TRAF6 → TBK1 (indirect_complex) Pomerantz et al., EMBO J 1999, Chariot et al., J Biol Chem 2002, Konno et al., PloS one 2009
• Reactome Reaction: TRAF6 → TBK1 (reaction) Pomerantz et al., EMBO J 1999, Chariot et al., J Biol Chem 2002, Paz et al., Cell Mol Biol Incl Cyto Enzymol 2006, Konno et al., PloS one 2009

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of TRAF2-MAVS-TRAF6-IKBKB-VDAC1-IRF3-TBK1 (colocalization, cosedimentation through density gradient) Hou et al., Cell 2011

Text-mined interactions from Literome

Sato et al., J Immunol 2003 : Because TRAF6 and TBK1 bind close the region of TRIF, it seems that TRAF6 physically prevents the association between TRIF and TBK1
Qu et al., Mol Cell Biol 2012 : TRAF6 was essential for IL-17 induced TBK1 activation, its association with Act1, and consequent Act1 phosphorylation