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TNF — ZFP36

Text-mined interactions from Literome

Inglot et al., Arch Immunol Ther Exp (Warsz) 1999 : TTP* stimulated synthesis of IFN and TNF in the whole blood cultures
Johnson et al., Oncogene 2000 : The immediate early protein tristetraprolin (TTP) is required to prevent inappropriate production of the cytokine TNF-alpha , and is a member of a zinc finger protein family that is associated with RNA binding ... TTP expression is induced by TNF-alpha , and evidence indicates that TTP can bind and destabilize the TNF-alpha mRNA
Fairhurst et al., Arthritis Res Ther 2003 : These data establish the cytoplasmic location of TTP, supporting a major role for this protein in regulating TNF production, and suggest that TTP levels are not regulated solely by TNF
Suzuki et al., J Exp Med 2003 : Furthermore, IL-4 induced the expression of tristetraprolin (TTP), an RNA binding protein that promotes decay of ARE containing mRNA, in mast cells by a Stat6 dependent mechanism, and the depletion of TTP expression by RNA interference prevented IL-4 induced down-regulation of TNF-alpha production in mast cells
Tsutsumi et al., J Rheumatol 2004 (Arthritis, Rheumatoid) : A low TTP/TNF-a gene expression ratio could indicate failure of RA patients to produce adequate amounts of TTP in response to increased TNF-a production
Fukae et al., Arthritis Rheum 2005 (Arthritis, Rheumatoid) : The effects of TIS11B on TNFalpha expression were examined using an overexpression model of TIS11B in RAW264.7 cells
Carrick et al., J Autoimmun 2006 (Arthritis, Rheumatoid...) : The ZFP36 gene codes for TTP , a regulator of TNF alpha
Smoak et al., Mol Cell Biol 2006 : Small interfering RNAs to TTP significantly prevent this effect, and a cell line stably expressing a short-hairpin RNA to TTP conclusively establishes that TTP is critical for dexamethasone inhibition of TNF-alpha mRNA expression
Deleault et al., Mol Immunol 2008 (MAP Kinase Signaling System) : Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways
Sze et al., Biochem J 2008 : Activation of the JNK signalling pathway by TNFalpha up-regulated the expression of an RNA binding protein, TTP ( tristetraprolin )
Jalonen et al., J Pharmacol Exp Ther 2008 : By binding to ARE, TTP increases the degradation of TNF-alpha mRNA, thereby reducing the expression of TNF-alpha
Semaan et al., PloS one 2011 (Arthritis, Rheumatoid) : Conversely, transfection of miR-346 in LPS activated THP-1 cells increased TTP mRNA expression and inhibited TNF-a release
Qi et al., Mol Cell Biol 2012 : Furthermore, knockdown of TTP increases the rate of biosynthesis of TNF-a , suggesting that TTP can exert effects at translational levels
Qin et al., Nutrition 2012 (MAP Kinase Signaling System) : Ex vivo, the CE significantly decreased the amount of apolipoprotein-B48 secretion into the media, inhibited the mRNA expression of genes of the inflammatory cytokines, interleukin-1ß, interleukin-6, and tumor necrosis factor-a , and induced the expression of the anti-inflammatory gene, Zfp36
Chen et al., Biochem Biophys Res Commun 2012 (Inflammation) : Excessive TNF-a expression induces tristetraprolin (TTP) , an RNA binding protein that regulates mRNA degradation, which in turn downregulates TNF and its downstream genes, thus resulting in anti-inflammatory effects
Liu et al., Carcinogenesis 2013 (Leukemia) : Overexpression of TTP suppressed HQ-induced TNF-a upregulation and restored the viability of HQ-treated cells
Ray et al., PloS one 2013 : Tristetraprolin mediates radiation induced TNF-a production in lung macrophages
Hochdörfer et al., Cell Signal 2013 : LPS induced production of TNF-a and IL-6 in mast cells is dependent on p38 but independent of TTP
Inglot et al., Arch Immunol Ther Exp (Warsz) 1993 : Tolpa Torf Preparation (TTP) induces interferon and tumor necrosis factor production in human peripheral blood leukocytes
Carballo et al., Science 1998 : Tristetraprolin (TTP) , the prototype of a class of Cys-Cys-Cys-His ( CCCH ) zinc finger proteins, inhibited TNF-alpha production from macrophages by destabilizing its messenger RNA