Tsai et al., Life Sci 2000
:
Production of tumor necrosis factor (TNF)-alpha and IL-1beta by mouse mesangial cells was not blocked by SSA but production of IL-4 by these cells was inhibited by it ( > 0.1 mM )
Gerl et al., Arthritis Rheum 2005
(Lupus Erythematosus, Cutaneous) :
TNFalpha induced up-regulation of 52-kd Ro/SSA mRNA expression peaked at 4 hours, followed by up-regulation of intracellular 52-kd Ro/SSA protein expression at 24 hours, independently of apoptosis
Dörner et al., Ann Rheum Dis 1995
:
TNF alpha mediates 52 kDa Ro(SS-A) and La ( SS-B ) autoantigen surface expression on human keratinocytes, and may be an important factor both in antibody induction and in the initiation of immunopathogenic processes which occur after antibody binding in autoimmune dermatitis