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TNF — TNFRSF11B

Text-mined interactions from Literome

Sakata et al., J Bone Miner Res 1999 : Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) increased OPG/OCIF mRNA levels in a dose-and time dependent manner in HPDL ... After 12 h of treatment, IL-1beta at 3 ng/ml and TNF-alpha at 3 ng/ml increased OPG/OCIF mRNA expression by 190 % and 110 %, respectively, with a maximal effect
Brändström et al., Biochem Biophys Res Commun 2001 : Using this ELISA, the amount of OPG secreted from human bone marrow stromal cells was clearly detectable, and the secretion of OPG-protein was potently regulated by prostaglandin E ( 2 ), forskolin, phorbol 12,13 di butyrate, IL-1 alpha, TNF-alpha , and dexamethasone
Li et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2003 : To investigate the effects of LPS and/or TNF-alpha on periodontal ligament cell ( PDLC ) proliferation and OPG secretion ... TNF-alpha prohibits the proliferation of PDLCs but enhances their OPG secretion
Kubota et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : Tumor necrosis factor-alpha promotes the expression of osteoprotegerin in rheumatoid synovial fibroblasts ... To clarify the regulation of osteoprotegerin (OPG) expression in rheumatoid synovial fibroblasts by investigating the effect of tumor necrosis factor-alpha (TNF-alpha) and the mechanism of TNF-alpha induced OPG expression ... TNF-alpha induced OPG expression in all synovial fibroblasts, even OA and noninflammatory fibroblasts, and expression occurred to a remarkable degree in RA fibroblasts ... TNF-alpha induced OPG expression was inhibited by hymenialdisine, a nuclear factor-kappaB inhibitor, in a dose dependent manner, and expression was inhibited by soluble TNF receptor/Fc fusion protein I ( TNFs-RI/Fc ), not by TNFs-RII/Fc ... TNF-alpha induced OPG expression is mediated predominantly through TNF-RI ... Although TNF-alpha is known to stimulate bone destruction, TNF-alpha induced upregulation of OPG may contribute to self-protection from the bone destruction in RA
Lavigne et al., Bone 2004 (Osteoarthritis...) : The ratio sRANKL/OPG was significantly increased with PMMA and TNF-alpha , and treatment with anti-IL-6 antibodies did not alter this ratio
Miyashita et al., Clin Exp Immunol 2004 (Arthritis, Rheumatoid) : Neither IL-6 nor tumour necrosis factor (TNF)-alpha increased the production of OPG from FLS
Dai et al., Ann Rheum Dis 2004 (Arthritis, Rheumatoid...) : IL18, IL1 beta, and TNF alpha did not induce M-CSF, GM-CSF, IFN gamma, or OPG production in PHA prestimulated T cells or RA synovial T cells
Marotte et al., Arthritis Res Ther 2005 (Arthritis, Rheumatoid...) : TNF-alpha induced IL-6 and OPG production by synoviocytes, which was further increased with patient plasma dilutions and inhibited by infliximab
Koreny et al., Arthritis Rheum 2006 (Bone Resorption...) : In addition, interface membrane fibroblasts expressed RANKL and osteoprotegerin in response to stimulation with conditioned media, TNFalpha , or IL-1beta
Ben-Tal Cohen et al., Biochem Pharmacol 2007 : Statins decrease TNF-alpha induced osteoprotegerin production by endothelial cells and smooth muscle cells in vitro ... Using an ELISA we could demonstrate that statins reduce tumor necrosis factor-alpha (TNF-alpha) induced OPG production in cultured human endothelial cells and smooth muscle cells ... A significant reduction of TNF-alpha induced OPG was seen when statins were used in the nanomolar range ... The effect of statins on TNF-alpha induced OPG production was reversed by mevalonate and geranyl-geranyl pyrophosphate at the level of protein production and at the level of mRNA expression, suggesting that it was brought about by inhibition of the mevalonic acid pathway and protein prenylation
Poubelle et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid...) : The expression of OPG and RANK by normal human blood neutrophils, however, can be induced by interleukin-4 + tumor necrosis factor-alpha and by SFs from patients with RA
Schrader et al., Diabetologia 2007 : The effects of IL-1beta and TNF-alpha on OPG expression were characterised by northern blot and immunoassay
An et al., Yonsei Med J 2007 : In contrast, tumor necrosis factor-alpha (TNF-alpha) increased the expression of both OPG and RANKL in a time dependent manner
Zhao et al., Cytokine 2008 (Arthritis, Rheumatoid) : Characterization of synovial cell clones isolated from rheumatoid arthritis patients : possible involvement of TNF-alpha in reduction of osteoprotegerin in synovium ... TNF-alpha induced apoptosis of SYM-1 cells within 24h and decreased OPG levels, while infliximab, a chimerical form of the anti-TNF-alpha antibody drug, suppressed the apoptosis and restored OPG levels ... These results suggest the existence of fibroblastic cells producing OPG in the synovium, while TNF-alpha suppresses OPG production by inducing apoptosis in those cells
Lee et al., Arthritis Res Ther 2011 (Arthritis, Gouty...) : MSU crystals induced the expressions of IL-1, IL-6, TNF-alpha and RANKL in PBMCs, but inhibited OPG expression
Oliver et al., Pigment Cell Melanoma Res 2013 (Melanoma...) : Differential expression and tumor necrosis factor mediated regulation of TNFRSF11b/osteoprotegerin production by human melanomas
Brändström et al., Biochem Biophys Res Commun 1998 (Bone Neoplasms...) : In this report we have examined the effect of tumor necrosis factor-alpha (TNF-alpha) and tumor necrosis factor-beta (TNF-beta) on OPG mRNA levels in the human osteosarcoma cell line MG-63
Hofbauer et al., Biochem Biophys Res Commun 1998 : Interleukin (IL)-1beta ( 5 x 10 ( -9 ) M ), tumor necrosis factor (TNF)-alpha ( 9 x 10 ( -9 ) M ), and bone morphogenetic protein (BMP)-2 ( 100 ng/ml ) also increased OPG mRNA levels in hFOB cells by 4-, 6-, and 4-fold, respectively