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GZMB — TNF
Text-mined interactions from Literome
Miyoshi et al., Eur J Pharmacol 2005
:
These findings suggest that
TNF-alpha plays a key role in endotoxin induced down-regulation of hepatic P-glycoprotein, as well as
plays a protective role in the regulation of hepatic CYP3A2 and
CYP2C11 against endotoxin induced acute inflammatory response
Ferran et al., Clin Exp Immunol 1991
:
145-2C11 induced significant release of
TNF and IL-2 in all four strains
Mishra et al., Immunobiology 2009
:
Our findings suggest that RAE
induces TLR-4 expression and intracellular
granzyme-B in treated splenocytes while RAE stimulated IL-1beta, IL-6, and
TNF-alpha in human PBMCs
Kageyama et al., Mod Rheumatol 2009
(Arthritis, Rheumatoid) :
TNF-alpha induced MCP-1, RANTES, and
granzyme B production in cultured synovial cells from RA patients
Alegre et al., Eur J Immunol 1990
(Hypoglycemia...) :
The release of
TNF induced by
145-2C11 depends on the effect of the mAb on T cells as it is not observed in athymic nude mice while lipopolysaccharide-resistant C3H/HeJ mice also display a significant rise in serum TNF ( peak levels at 2 h : 59 +/- 44 pg/ml )
Anguille et al., PloS one 2012
(Neoplasms) :
The cytotoxicity of IL-15 DCs is predominantly mediated by
granzyme B and, to a small extent, by tumor necrosis factor-a (TNF-a) related apoptosis inducing ligand ( TRAIL ) but is
independent of perforin, Fas ligand and
TNF-a