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FBXO32 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Li et al., FASEB J 2005
:
Since the cytokine tumor necrosis factor-alpha (TNF-alpha) stimulates both reactive oxygen production and general activity of the ubiquitin conjugating pathway, we hypothesized that
TNF-alpha would also
increase atrogin1/MAFbx gene expression ... The increase in
atrogin1/MAFbx gene expression
induced by
TNF-alpha was not altered significantly by ERK inhibitor PD98059 or the JNK inhibitor SP600125
Adams et al., Cardiovasc Res 2007
(Heart Failure...) :
In neonatal rat cardiomyocytes,
TNF-alpha induced the expression of
MAFbx through p38MAPK dependent pathways, whereas the induction of Murf-1 required the activation of the p42/44 MAPK pathway