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PTPN2 — STAT3

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by TCPTP: TCPTP p45 (PTPN2) → STAT3 (dimer)-active complex (STAT3) (modification, activates)
  Yamamoto et al., Biochem Biophys Res Commun 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT3 — PTPN2 (physical association, affinity chromatography technology) Yamamoto et al., Biochem Biophys Res Commun 2002*
• IRef Hprd Interaction: STAT3 — PTPN2 (in vivo) Yamamoto et al., Biochem Biophys Res Commun 2002*, Blanchetot et al., Methods 2005
• IRef Hprd Interaction: STAT3 — PTPN2 (in vitro) Yamamoto et al., Biochem Biophys Res Commun 2002*, Blanchetot et al., Methods 2005
• IRef Ophid Interaction: STAT3 — PTPN2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shields et al., Cell cycle (Georgetown, Tex.) 2008 : Cell cycle dependent regulation of SFK, JAK1 and STAT3 signalling by the protein tyrosine phosphatase TCPTP
Yuan et al., J Biol Chem 2010 (Breast Neoplasms...) : Furthermore, PTPN9 WT expression specifically impairs EGF induced STAT3 and STAT5 activation, and inhibits the cell growth in soft agar
Shields et al., Mol Cell Biol 2013 (Breast Neoplasms) : Homozygous TCPTP deficiency in murine mammary fat pads in vivo is associated with elevated SFK and STAT3 signaling, whereas TCPTP deficiency in human breast cancer cell lines enhances SFK and STAT3 signaling