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PIAS1 — STAT1

Pathways - manually collected, often from reviews:

• KEGG Jak-STAT signaling pathway: PIAS1/PIAS2/PIAS3/PIAS4 → STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6 (protein-protein, inhibition)
  
• KEGG Hepatitis C: PIAS1/PIAS2/PIAS3/PIAS4 → STAT1/STAT2 (protein-protein, inhibition)
• NCI Pathway Database Signaling events mediated by TCPTP: PIAS1 (PIAS1) → STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: PIAS1 (PIAS1) → STAT1 (dimer) complex (STAT1) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: PIAS1 (PIAS1) → STAT1 (dimer)/TCPTP p45 complex (STAT1-PTPN2) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → TCPTP p45 (PTPN2) (modification, collaborate) Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → STAT1 (dimer) complex (STAT1) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by TCPTP: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → STAT1 (dimer)/TCPTP p45 complex (STAT1-PTPN2) (modification, collaborate)
  Zhu et al., J Biol Chem 2002*, Wang et al., J Biol Chem 2006*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IFN-gamma pathway: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → STAT1 (dimer) complex (STAT1) (Antiviral Response, inhibits)
  Varinou et al., Immunity 2003, Liu et al., Nat Immunol 2004*, Meraz et al., Cell 1996*, Durbin et al., Cell 1996*
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL6-mediated signaling events: PIAS1 (PIAS1) → STAT1 (STAT1) (modification, collaborate) Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: PIAS1 (PIAS1) → STAT1/PIAS1 complex (STAT1-PIAS1) (modification, collaborate)
  Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → STAT1/PIAS1 complex (STAT1-PIAS1) (modification, activates)
  Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: STAT1 (STAT1) → STAT1/PIAS1 complex (STAT1-PIAS1) (modification, collaborate)
  Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: physical interaction
• NCI Pathway Database IFN-gamma pathway: PIAS1 (PIAS1) → STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) (modification, collaborate)
  Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Liu et al., Nat Immunol 2004*, Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: PIAS1 (PIAS1) → STAT1 (dimer) complex (STAT1) (modification, collaborate)
  Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Liu et al., Nat Immunol 2004*, Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → STAT1 (dimer) complex (STAT1) (modification, collaborate)
  Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Liu et al., Nat Immunol 2004*, Liu et al., Proc Natl Acad Sci U S A 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IFN-gamma pathway: STAT1 (dimer)/PIAS1 complex (STAT1-PIAS1) → STAT1 (dimer) complex (STAT1) (Antibacterial Response, inhibits)
  Varinou et al., Immunity 2003, Liu et al., Nat Immunol 2004*, Meraz et al., Cell 1996*
  Evidence: mutant phenotype, other species
• Reactome Reaction: PIAS1 → STAT1 (indirect_complex) Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Palvimo et al., Biochem Soc Trans 2007*
• Reactome Reaction: PIAS1 → STAT1 (reaction) Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Palvimo et al., Biochem Soc Trans 2007*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PIAS1 — STAT1 Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Bind_translation Interaction: PIAS1 — STAT1 (unspecified method) Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Biogrid Interaction: PIAS1 — STAT1 (direct interaction, two hybrid) Liao et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: PIAS1 — STAT1 (physical association, affinity chromatography technology) Reardon et al., J Immunol 2007*
• IRef Biogrid Interaction: PIAS1 — STAT1 (physical association, affinity chromatography technology) Mowen et al., Cell 2001*
• IRef Biogrid Interaction: PIAS1 — STAT1 (physical association, affinity chromatography technology) Weber et al., Genes Dev 2009*
• IRef Biogrid Interaction: PIAS1 — STAT1 (physical association, affinity chromatography technology) Liu et al., J Immunol 2008*
• IRef Biogrid Interaction: PIAS1 — STAT1 (physical association, affinity chromatography technology) Zhu et al., J Biol Chem 2002*
• IRef Biogrid Interaction: PIAS1 — STAT1 (physical association, affinity chromatography technology) Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Biogrid Interaction: PIAS1 — STAT1 (direct interaction, pull down) Liao et al., Proc Natl Acad Sci U S A 2000*
• IRef Hprd Interaction: PIAS1 — STAT1 (two hybrid) Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Hprd Interaction: PIAS1 — STAT1 (in vivo) Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Hprd Interaction: PIAS1 — STAT1 (in vitro) Liao et al., Proc Natl Acad Sci U S A 2000*, Ungureanu et al., Blood 2003*, Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Mppi Interaction: PIAS1 — STAT1 (coimmunoprecipitation) Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Mppi Interaction: PIAS1 — STAT1 (two hybrid) Liu et al., Proc Natl Acad Sci U S A 1998
• IRef Ophid Interaction: PIAS1 — STAT1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Hwang et al., Mol Endocrinol 2004 (Carcinoma, Papillary...) : RET/PTC induced STAT1 transcriptional activation was not inhibited by suppressor of cytokine signaling-1 or -3, or protein inhibitors of activated STAT3 [ ( protein inhibitor of activated STAT ( PIAS3 ) ], but PIAS1 strongly repressed the RET/PTC induced transcriptional activity of STAT1
Ramsauer et al., Proc Natl Acad Sci U S A 2007 : Together, the data support the assumption that the main role of STAT1 in activating gbp2 transcription is to provide transcriptionally competent chromatin, whereas the function of IRF1 may lie in directly contacting RNA polymerase II-containing transcriptional complexes
Liu et al., Proc Natl Acad Sci U S A 1998 : PIAS1 , but not other PIAS proteins, blocked the DNA binding activity of Stat1 and inhibited Stat1 mediated gene activation in response to interferon ... The in vivo PIAS1-Stat1 interaction requires phosphorylation of Stat1 on Tyr-701