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FOXO4 — SIRT1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Oh et al., Mol Pharmacol 2010
:
Overexpression of
SIRT1 enhanced both
FoxO reporter activity and nuclear levels of FoxO1
Xiong et al., J Biol Chem 2011
:
Consistently,
FoxO1 overexpression
increases SIRT1 expression, and FoxO1 depletion by siRNA reduces SIRT1 expression at both the messenger RNA and protein levels in vascular smooth muscle cells and HEK293 cells
Rizki et al., PLoS Genet 2011
:
The conserved DAF-16/FOXO transcription factors and SIR-2.1/SIRT1 deacetylases are critical for diverse biological processes, particularly longevity and stress response ; and complex
regulation of
DAF-16/FOXO by
SIR-2.1/SIRT1 is central to appropriate biological outcomes
Parker et al., J Neurosci 2012
:
In Caenorhabditis elegans,
sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine ( polyQ ) toxicity, and this protection
requires the longevity promoting factor
daf-16/FOXO