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NCF2 — RAC2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RAC2
—
NCF2
(direct interaction, pull down)
Ahmed et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
RAC2
—
NCF2
(direct interaction, two hybrid)
Faris et al., Biochem Biophys Res Commun 1998*
-
IRef Hprd Interaction:
RAC2
—
NCF2
(in vivo)
Ahmed et al., J Biol Chem 1998*, Faris et al., Biochem Biophys Res Commun 1998*
-
IRef Intact Interaction:
RAC2
—
NCF2
(physical association, isothermal titration calorimetry)
Lapouge et al., Mol Cell 2000*
-
IRef Ophid Interaction:
RAC2
—
NCF2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Nisimoto et al., Biochemistry 2004
:
In the
presence of
Rac , p67N or
p67phox bound to gp91C with a molar ratio of approximately 1 : 1 but neither p67N nor Rac alone showed significant binding
Robinson et al., Histochem Cell Biol 2004
:
X-ray crystallography and NMR spectroscopy have provided detailed structural data on these domains and how p47-phox and
p67-phox interact with p22-phox and
activated Rac , respectively
Choi et al., Int Immunopharmacol 2006
:
Translocation of p47(phox), p67(phox) and
Rac was increased in response to PMA, and Tau-Cl
inhibited the PMA stimulated translocation of p47(phox) and
p67(phox) to plasma membrane without affecting the translocation of Rac
Dorseuil et al., J Biol Chem 1996
:
These results indicate that activated
Rac can
regulate NADPH oxidase by interacting with
p67phox and that Rac2 is the main p67phox interacting GTPase in human cells