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CXCL12 — RAC2

Text-mined interactions from Literome

Takesono et al., Curr Biol 2004 : Expression of a dominant negative Itk impaired SDF-1alpha induced migration, cell polarization, and activation of Rac and Cdc42
García-Bernal et al., Mol Biol Cell 2005 : CXCL12 activates the GTPase Rac , as well as Vav1, a guanine-nucleotide exchange factor for Rac, concomitant with up-regulation of alpha4beta1 dependent adhesion ... Importantly, inhibition of Vav1 expression by RNA interference resulted in a blockade of Rac activation in response to CXCL12 ... Adhesions in flow chambers and soluble binding assays using these transfectants indicated that initial ligand binding and adhesion strengthening mediated by alpha4beta1 were dependent on Vav1 and Rac activation by CXCL12
Bartolomé et al., Cancer Res 2006 (Melanoma...) : Blocking Vav expression by RNA interference results in impaired activation of Rac and Rho by CXCL12 and in a remarkable inhibition of CXCL12 promoted invasion
Tan et al., J Biol Chem 2006 (Neoplasm Metastasis) : We observed that whereas G ( i ) and Gbetagamma subunits are involved in SDF-1 induced Rac activation and cell migration, CXCR4 can also stimulate Rho potently leading to the phosphorylation of myosin light chain through the Rho effector, Rho kinase, but independently of G ( i )
Fuhler et al., Blood 2008 (MAP Kinase Signaling System...) : Furthermore, SDF-1 stimulated activation of Rac and the PI3K target protein kinase B is impaired in CD34 ( + ) cells from MDS patients ... In addition, expression of constitutive active Rac increases the motility of MDS CD34 ( + ) cells in the absence of SDF-1 , although the directional migration of cells toward this chemoattractant is not affected
Sai et al., J Biol Chem 2008 : Parallel phosphatidylinositol 3-kinase (PI3K) dependent and Src dependent pathways lead to CXCL8 mediated Rac2 activation and chemotaxis