◀ Back to PI3
PI3 — RAC1
Text-mined interactions from Literome
Beeton et al., Mol Cell Biol Res Commun 1999
:
However, the ability of activated
Rac to
stimulate PI 3-kinase activity was only observed in heterodimers containing the p85alpha and deltaSH3-p85alpha, indicating that rac binding to the BH domain is responsible for rac induced stimulation of class Ia PI 3-kinase
Gille et al., J Biol Chem 1999
:
Activated
PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB, and to a lesser extent the Rho family GTPase
Rac
Katagiri et al., Mol Cell Biol 2000
:
H-Ras and
Rac activated LFA-1 in a
PI 3-kinase dependent manner, whereas Rho and R-Ras had little effect
Banyard et al., Oncogene 2000
:
We also show that constitutively active
V12-Rac significantly stimulated basal Rat1 fibroblast invasion,
independent of
PI-3-kinase activity, and that this effect was suppressed by the effector mutant V12/H40-Rac
Sanlioglu et al., J Virol 2000
:
Inhibition of
Rac1 using a dominant N17Rac1 mutant
led to a decrease in AAV-2 mediated
PI3 kinase activation, indicating that Rac1 may act proximal to PI3 kinase during AAV-2 infection
Storey et al., Curr Biol 2002
:
Rho
stimulation by G ( 13 ) -coupled receptors and
Rac stimulation by nuclear hormones through
PI3-kinase may be general mechanisms for regulating ion channel activity in many cell types
Arai et al., Oncogene 2002
:
In addition, the cytokine induced
Rac activation was
inhibited by a
phosphatidyl-inositol 3'-kinase (PI3K) inhibitor, LY294002, which also inhibited the Erk activation
Yamamori et al., Biochem Biophys Res Commun 2002
:
Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002,
blocked not only p38 MAPK activation but also
Rac activation
Lee et al., J Biol Chem 2003
(Carcinoma, Hepatocellular) :
The exact link between selenite treatment,
Rac1 activation , and activation of the focal adhesion
kinase-PI 3-kinase , however, remains to be characterized
Marcoux et al., Oncogene 2003
:
Our further functional studies identified Vav2, a known exchange factor for Rac, as a crucial downstream component in EGFR- and
PI 3-kinase dependent
Rac activation upon integrin mediated cell adhesion
Brantley-Sieders et al., J Cell Sci 2004
(Neovascularization, Pathologic) :
Ephrin-A1 stimulation induces
PI3-kinase dependent activation of
Rac1 in wild-type endothelial cells, whereas EphA2-deficient cells fail to activate Rac1 upon stimulation
Felekkis et al., Mol Cancer Res 2005
(Breast Neoplasms) :
As
phosphatidylinositol 3-kinase (PI3K) signaling can
regulate Rac activation, we examined the effects of AND-34 on PI3K
Vecchione et al., J Exp Med 2005
(Hypertension) :
In response to angiotensin II,
PI3Kgamma was
required for the activation of
Rac and the subsequent triggering of ROS production
Pan et al., J Neurochem 2005
:
RA-induced activation of
Rac1 is
mediated by
phosphatidylinositol 3-kinase (PI3K) , probably because of phosphorylation of the p85 regulatory subunit by Src kinases
Vedham et al., Mol Cell Biol 2005
:
We conclude that Vav acts as a
PI 3-kinase dependent activator for
Rac activation in macrophages stimulated with M-CSF and that SHIP regulates macrophage M-CSF triggered chemotaxis by hydrolysis of PI ( 3,4,5 ) P ( 3 )
Di Marzio et al., Biochem Biophys Res Commun 2005
:
Moreover, this MIP-1alpha induced
Rac activation and consequent lamellipodia formation is Gi- and
phosphoinositide-3 kinase (PI3K) mediated
Alblas et al., Mol Cell Biol 2005
:
Furthermore, SIRPalpha induced NO production required the generation of hydrogen peroxide ( H ( 2 ) O ( 2 ) ) by a NADPH oxidase ( NOX ) and the
phosphatidylinositol 3-kinase (PI3-K) dependent
activation of
Rac1 , an intrinsic NOX component
Park et al., Cancer Res 2005
(Fibrosarcoma...) :
Consistent with the increased cell migration/invasion of syndecan-2 overexpressing HT1080 cells, syndecan-2 overexpression increased phosphorylation and interaction of focal adhesion kinase ( FAK ) and
phosphatidylinositol 3-kinase (PI3K) , membrane localization of T-lymphoma invasion and metastasis gene-1 ( Tiam-1 ), and
activation of
Rac
Gonzalez et al., J Biol Chem 2006
:
Taken together, these studies identify G protein betagamma subunits, Src kinase and the GEF Tiam1 as upstream modulators of S1P mediated Rac1 activation, and establish a central
role for
Rac1 in S1P mediated activation of
PI 3-kinase/Akt/endothelial nitric-oxide synthase signaling in vascular endothelial cells
Seveau et al., Cell Microbiol 2007
:
PI 3-kinase activation was upstream and
independent of
Rac1 activation
Nielsen-Preiss et al., Endocrinology 2007
:
In addition,
PI3K inhibition in GnRH neuronal cells
diminished Gas6 induced
Rac activation
Aoki et al., J Cell Biol 2007
:
Further refinement of the computational model predicted
Rac1 regulation of
PI3-kinase and SHIP2, which was also validated experimentally
Jin et al., Neurochem Int 2007
:
These results suggest that the NGF induced ruffling requires activation of
Rac1 and Cdc42, but does not
require Ras,
PI-3k , Akt and GSK-3beta
Yip et al., J Cell Sci 2007
(Adenocarcinoma) :
Both
Rac and Ras have been shown to regulate actin polymerization and
activate PI 3-kinase
Leventhal et al., Trends Endocrinol Metab 1997
:
This effect of the IGFs is mediated by activation and autophosphorylation of the type I IGF receptor, followed by docking of insulin receptor substrate-1 (IRS-1), stimulation of
phosphatidylinositol (PI) 3-kinase , and possibly
activation of the small GTPase
Rac
Hubchak et al., American journal of physiology. Renal physiology 2009
(Fibrosis) :
Rac1 activation
required phosphatidylinositol-3-kinase (PI3K) activity
Xia et al., Journal of thrombosis and haemostasis : JTH 2010
:
Subsequently,
PI3K overexpression
activated Rac1 and increased ROS generation
Jeanes et al., J Mol Histol 2009
:
This is independent of potential effects on adhesion or polarity, but may occur through
PI3-kinase stimulated
Rac signaling
Zhang et al., J Cell Mol Med 2011
(Endotoxemia...) :
The aim of this study was to investigate the role of Rac1 in TNF-a expression and cardiac dysfunction during endotoxemia and to determine the
involvement of
phosphoinositide-3 kinase (PI3K) in lipopolysaccharide (LPS) induced
Rac1 activation
Kim et al., Exp Mol Med 2012
(Diabetes Mellitus, Experimental...) :
The
phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, simultaneously
regulates Rac1 and Cdc42, which destabilize the podocyte actin cytoskeleton during early DN
Koch et al., Neurobiol Dis 2013
:
This correlates with the reggie-1 dependent
activation of Src and
PI3 kinase (PI3K) , of the Rho family GTPase
Rac1 and downstream effectors such as cofilin
Spillane et al., J Neurosci 2012
:
The effects of NGF on
Rac1 activity and increases in axonal levels of WAVE1 and cortactin were both
dependent on
phosphoinositide 3-kinase (PI3K) signaling
Basquin et al., Communicative & integrative biology 2013
:
Thus,
PI3K regulates both the activation of
Rac1 and its recruitment during IL-2R endocytosis
Zheng et al., J Biol Chem 1994
:
These findings suggest that
PI 3-kinase , through the Rho-GAP homology domain of p85, can couple to the effector domain of Cdc42Hs and that p85 may be a
target for the GTP bound forms of Cdc42Hs and
Rac1